The relationship between survival and the extent of the resection in patients with supratentorial malignant gliomas

M. R. Quigley, J. C. Maroon, J. M. Piepmeier, Edward Neuwelt

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Current neurosurgical opinion favors the radical surgical removal of supratentorial gliomas, when feasible, in the belief that this optimizes patient survival. Although bolstered by the results of some early investigators, the efficacy of this approach remains debatable. Therefore, we undertook a review of the English language literature of the past 30 years for a series of surgically treated malignant gliomas. Twenty reports comprising 5691 patients were identified. Only 4 found the extent of the surgical resection related to survival. In 2 of these, it followed age, histological findings, and performance status in importance. The 2 other studies did not rank the prognostic variables at all. On closer inspection, however, there does appear to be a subgroup of young patients with favorable histological findings and good performance status for whom surgery is beneficial. Future reporting of surgical results of patients with gliomas will require stratification by the known prognostic variables of age, histological findings, and performance status to characterize better this subgroup for whom surgery is beneficial.

Original languageEnglish (US)
Pages (from-to)385-389
Number of pages5
JournalNeurosurgery
Volume29
Issue number3
StatePublished - 1991
Externally publishedYes

Fingerprint

Glioma
Survival
Language
Research Personnel

Keywords

  • Astrocytoma
  • Outcome
  • Prognostic factors
  • Supratentorial tumor

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

The relationship between survival and the extent of the resection in patients with supratentorial malignant gliomas. / Quigley, M. R.; Maroon, J. C.; Piepmeier, J. M.; Neuwelt, Edward.

In: Neurosurgery, Vol. 29, No. 3, 1991, p. 385-389.

Research output: Contribution to journalArticle

@article{d8d429abdcf64e04b9d2470ece9dcb00,
title = "The relationship between survival and the extent of the resection in patients with supratentorial malignant gliomas",
abstract = "Current neurosurgical opinion favors the radical surgical removal of supratentorial gliomas, when feasible, in the belief that this optimizes patient survival. Although bolstered by the results of some early investigators, the efficacy of this approach remains debatable. Therefore, we undertook a review of the English language literature of the past 30 years for a series of surgically treated malignant gliomas. Twenty reports comprising 5691 patients were identified. Only 4 found the extent of the surgical resection related to survival. In 2 of these, it followed age, histological findings, and performance status in importance. The 2 other studies did not rank the prognostic variables at all. On closer inspection, however, there does appear to be a subgroup of young patients with favorable histological findings and good performance status for whom surgery is beneficial. Future reporting of surgical results of patients with gliomas will require stratification by the known prognostic variables of age, histological findings, and performance status to characterize better this subgroup for whom surgery is beneficial.",
keywords = "Astrocytoma, Outcome, Prognostic factors, Supratentorial tumor",
author = "Quigley, {M. R.} and Maroon, {J. C.} and Piepmeier, {J. M.} and Edward Neuwelt",
year = "1991",
language = "English (US)",
volume = "29",
pages = "385--389",
journal = "Neurosurgery",
issn = "0148-396X",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - The relationship between survival and the extent of the resection in patients with supratentorial malignant gliomas

AU - Quigley, M. R.

AU - Maroon, J. C.

AU - Piepmeier, J. M.

AU - Neuwelt, Edward

PY - 1991

Y1 - 1991

N2 - Current neurosurgical opinion favors the radical surgical removal of supratentorial gliomas, when feasible, in the belief that this optimizes patient survival. Although bolstered by the results of some early investigators, the efficacy of this approach remains debatable. Therefore, we undertook a review of the English language literature of the past 30 years for a series of surgically treated malignant gliomas. Twenty reports comprising 5691 patients were identified. Only 4 found the extent of the surgical resection related to survival. In 2 of these, it followed age, histological findings, and performance status in importance. The 2 other studies did not rank the prognostic variables at all. On closer inspection, however, there does appear to be a subgroup of young patients with favorable histological findings and good performance status for whom surgery is beneficial. Future reporting of surgical results of patients with gliomas will require stratification by the known prognostic variables of age, histological findings, and performance status to characterize better this subgroup for whom surgery is beneficial.

AB - Current neurosurgical opinion favors the radical surgical removal of supratentorial gliomas, when feasible, in the belief that this optimizes patient survival. Although bolstered by the results of some early investigators, the efficacy of this approach remains debatable. Therefore, we undertook a review of the English language literature of the past 30 years for a series of surgically treated malignant gliomas. Twenty reports comprising 5691 patients were identified. Only 4 found the extent of the surgical resection related to survival. In 2 of these, it followed age, histological findings, and performance status in importance. The 2 other studies did not rank the prognostic variables at all. On closer inspection, however, there does appear to be a subgroup of young patients with favorable histological findings and good performance status for whom surgery is beneficial. Future reporting of surgical results of patients with gliomas will require stratification by the known prognostic variables of age, histological findings, and performance status to characterize better this subgroup for whom surgery is beneficial.

KW - Astrocytoma

KW - Outcome

KW - Prognostic factors

KW - Supratentorial tumor

UR - http://www.scopus.com/inward/record.url?scp=0026076377&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026076377&partnerID=8YFLogxK

M3 - Article

VL - 29

SP - 385

EP - 389

JO - Neurosurgery

JF - Neurosurgery

SN - 0148-396X

IS - 3

ER -