The ratio of entropy to enthalpy for thermal transitions in biological cells, tissues and materials, and its implications for biology

Steven Jacques

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The process of irreversible thermal denaturation of macromolecules involves cooperative bond breakage. Many bonds must break at the same time to allow denaturation. Hence, molecules are stabilized against thermal damage. However, these multiple bonds enforce a structural order on the macromolecule. A review of the literature on the entropy AS (J/(mole K)) and enthalpy ΔH (J/mole) of various endpoints of irreversible thermal denaturation (eg., whitening, contraction, loss of birefringence, necrosis, onset of heat shock proteins) indicate that the ratio ΔS/ΔH is constant at a value of 31.47×10-4 K-1, or 1/Tcrit where T crit ≈ 44.6°C. The free energy of denaturation is ΔG = ΔH - TΔS. At temperatures below Tcrit, more cooperative bonds yield more stability because AH dominates over TΔS, but at temperatures above Tcrit more bonds yield less stable structure because TΔS dominates over ΔH. Only one free parameter describes the kinetics of irreversible denaturation of macromolecules involving simultaneous breakage of multiple cooperative bonds, the ΔH of the transition.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6435
DOIs
StatePublished - 2007
EventOptical Interactions with Tissue and Cells XVIII - San Jose, CA, United States
Duration: Jan 22 2007Jan 24 2007

Other

OtherOptical Interactions with Tissue and Cells XVIII
CountryUnited States
CitySan Jose, CA
Period1/22/071/24/07

Fingerprint

Denaturation
Enthalpy
Entropy
Tissue
Macromolecules
Birefringence
Free energy
Hot Temperature
Proteins
Temperature
Molecules
Kinetics

Keywords

  • Coagulation
  • Denaturation
  • Enthalpy
  • Entropy
  • Thermal damage

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Jacques, S. (2007). The ratio of entropy to enthalpy for thermal transitions in biological cells, tissues and materials, and its implications for biology. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 6435). [643502] https://doi.org/10.1117/12.715189

The ratio of entropy to enthalpy for thermal transitions in biological cells, tissues and materials, and its implications for biology. / Jacques, Steven.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6435 2007. 643502.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Jacques, S 2007, The ratio of entropy to enthalpy for thermal transitions in biological cells, tissues and materials, and its implications for biology. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 6435, 643502, Optical Interactions with Tissue and Cells XVIII, San Jose, CA, United States, 1/22/07. https://doi.org/10.1117/12.715189
Jacques, Steven. / The ratio of entropy to enthalpy for thermal transitions in biological cells, tissues and materials, and its implications for biology. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6435 2007.
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