The protective effects of 15-deoxy-Δ-12,14-prostaglandin J2 in spinal cord injury

Bradley J. Kerr, Elizabeth I. Girolami, Nader Ghasemlou, Young Jeong Suh, Samuel David

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Secondary tissue damage that occurs within days after spinal cord injury contributes significantly to permanent paralysis, sensory loss, and other functional disabilities. The acute inflammatory response is thought to contribute largely to this secondary damage. We show here that 15-deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ 2), a metabolite of prostaglandin D2 (PGD2) that has anti-inflammatory actions, given daily for the first 2 weeks after spinal cord contusion injury in mice, results in significant improvement of sensory and locomotor function. 15d-PGJ2-treated mice also show diminished signs of microglia/macrophage activation, increased neuronal survival, greater serotonergic innervation, and reduced demyelination in the injured spinal cord. These changes are accompanied by a reduction in chemokine and pro-inflammatory cytokine expression. Our results also indicate that 15d-PGJ2 is likely to reduce inflammation in the injured spinal cord by attenuating multiple signaling pathways: reducing activation of NF-κB; enhancing expression of suppressor of cytokine signaling1, and reducing the activation of Janus activated Kinase 2.

Original languageEnglish (US)
Pages (from-to)436-448
Number of pages13
JournalGLIA
Volume56
Issue number4
DOIs
StatePublished - Mar 2008
Externally publishedYes

Keywords

  • Cytokines
  • Demyelination
  • Inflammation
  • JAK2
  • NF-κB
  • PPARγ
  • SOCS1

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

Fingerprint

Dive into the research topics of 'The protective effects of 15-deoxy-Δ-<sup>12,14</sup>-prostaglandin J<sub>2</sub> in spinal cord injury'. Together they form a unique fingerprint.

Cite this