TY - JOUR
T1 - The placental transfer of acetylsalicyclic acid in near-term ewes
AU - Anderson, Debra F.
AU - Phernetton, Terrance M.
AU - Rankin, John H.G.
N1 - Funding Information:
From the Departments of Physiology and Gyrwology-Obstetrics, University of Wisconsin Medical Sthooi, and Wisconsin Petimtal Center, Madtson Gmrml Hospital. Supported by National Institutes I$ Health Grant HDI 1185.
PY - 1980/3/15
Y1 - 1980/3/15
N2 - The placental transfer of acetylsalicylic acid was studied in five near-term ewes and fetuses. The total clearance (Ctot) of acetylsalicylic acid from the fetal compartment was determined by bolus injection of 14C-acetylsalicylic acid into the fetal compartment. Ctot = Cp + Cf where Cp is the placental clearance and Cf is the fetal tissue clearance. 14C-acetylsalicylic acid was then infused into the ewe. Fetal (F) and maternal (M) steady-state concentrations of acetylsalicylic acid were measured. During steady-state conditions, the influx of acetylsalicylic acid into the fetal compartment will equal the efflux, or Cp × (M-F) = Cf × F. Combining these two equations yields the following description of placental clearance: Cp = Ctot × F M. Using this equation, we calculated Cp = 0.57 ± 0.12 ml/min · kg and Cf = 1.93 ± 0.22 ml/min · kg. Maternal and fetal placental flows were also measured using radioactively labeled microspheres. From these flows, a 99% degree of diffusion limitation was determined for the placental transfer of acetylsalicylic acid.
AB - The placental transfer of acetylsalicylic acid was studied in five near-term ewes and fetuses. The total clearance (Ctot) of acetylsalicylic acid from the fetal compartment was determined by bolus injection of 14C-acetylsalicylic acid into the fetal compartment. Ctot = Cp + Cf where Cp is the placental clearance and Cf is the fetal tissue clearance. 14C-acetylsalicylic acid was then infused into the ewe. Fetal (F) and maternal (M) steady-state concentrations of acetylsalicylic acid were measured. During steady-state conditions, the influx of acetylsalicylic acid into the fetal compartment will equal the efflux, or Cp × (M-F) = Cf × F. Combining these two equations yields the following description of placental clearance: Cp = Ctot × F M. Using this equation, we calculated Cp = 0.57 ± 0.12 ml/min · kg and Cf = 1.93 ± 0.22 ml/min · kg. Maternal and fetal placental flows were also measured using radioactively labeled microspheres. From these flows, a 99% degree of diffusion limitation was determined for the placental transfer of acetylsalicylic acid.
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U2 - 10.1016/0002-9378(80)90461-5
DO - 10.1016/0002-9378(80)90461-5
M3 - Article
C2 - 7355969
AN - SCOPUS:0018877037
SN - 0002-9378
VL - 136
SP - 814
EP - 818
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 6
ER -