The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution

Deanne M. Taylor, Bruce J. Aronow, Kai Tan, Kathrin Bernt, Nathan Salomonis, Casey S. Greene, Alina Frolova, Sarah E. Henrickson, Andrew Wells, Liming Pei, Jyoti K. Jaiswal, Jeffrey Whitsett, Kathryn E. Hamilton, Sonya A. MacParland, Judith Kelsen, Robert O. Heuckeroth, S. Steven Potter, Laura A. Vella, Natalie A. Terry, Louis R. GhanemBenjamin C. Kennedy, Ingo Helbig, Kathleen E. Sullivan, Leslie Castelo-Soccio, Arnold Kreigstein, Florian Herse, Martijn C. Nawijn, Gerard H. Koppelman, Melissa Haendel, Nomi L. Harris, Jo Lynne Rokita, Yuanchao Zhang, Aviv Regev, Orit Rozenblatt-Rosen, Jennifer E. Rood, Timothy L. Tickle, Roser Vento-Tormo, Saif Alimohamed, Monkol Lek, Jessica C. Mar, Kathleen M. Loomes, David M. Barrett, Prech Uapinyoying, Alan H. Beggs, Pankaj B. Agrawal, Yi Wen Chen, Amanda B. Muir, Lana X. Garmire, Scott B. Snapper, Javad Nazarian, Steven H. Seeholzer, Hossein Fazelinia, Larry N. Singh, Robert B. Faryabi, Pichai Raman, Noor Dawany, Hongbo Michael Xie, Batsal Devkota, Sharon J. Diskin, Stewart A. Anderson, Eric F. Rappaport, William Peranteau, Kathryn A. Wikenheiser-Brokamp, Sarah Teichmann, Douglas Wallace, Tao Peng, Yang yang Ding, Man S. Kim, Yi Xing, Sek Won Kong, Carsten G. Bönnemann, Kenneth D. Mandl, Peter S. White

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan. We discuss the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.

Original languageEnglish (US)
Pages (from-to)10-29
Number of pages20
JournalDevelopmental Cell
Volume49
Issue number1
DOIs
StatePublished - Apr 8 2019

Fingerprint

Pediatrics
Atlases
Human Development
Growth
Gene expression
Cells
Health
Tissue
Gene Expression
Critical Pathways
Morphogenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

Cite this

Taylor, D. M., Aronow, B. J., Tan, K., Bernt, K., Salomonis, N., Greene, C. S., ... White, P. S. (2019). The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Developmental Cell, 49(1), 10-29. https://doi.org/10.1016/j.devcel.2019.03.001

The Pediatric Cell Atlas : Defining the Growth Phase of Human Development at Single-Cell Resolution. / Taylor, Deanne M.; Aronow, Bruce J.; Tan, Kai; Bernt, Kathrin; Salomonis, Nathan; Greene, Casey S.; Frolova, Alina; Henrickson, Sarah E.; Wells, Andrew; Pei, Liming; Jaiswal, Jyoti K.; Whitsett, Jeffrey; Hamilton, Kathryn E.; MacParland, Sonya A.; Kelsen, Judith; Heuckeroth, Robert O.; Potter, S. Steven; Vella, Laura A.; Terry, Natalie A.; Ghanem, Louis R.; Kennedy, Benjamin C.; Helbig, Ingo; Sullivan, Kathleen E.; Castelo-Soccio, Leslie; Kreigstein, Arnold; Herse, Florian; Nawijn, Martijn C.; Koppelman, Gerard H.; Haendel, Melissa; Harris, Nomi L.; Rokita, Jo Lynne; Zhang, Yuanchao; Regev, Aviv; Rozenblatt-Rosen, Orit; Rood, Jennifer E.; Tickle, Timothy L.; Vento-Tormo, Roser; Alimohamed, Saif; Lek, Monkol; Mar, Jessica C.; Loomes, Kathleen M.; Barrett, David M.; Uapinyoying, Prech; Beggs, Alan H.; Agrawal, Pankaj B.; Chen, Yi Wen; Muir, Amanda B.; Garmire, Lana X.; Snapper, Scott B.; Nazarian, Javad; Seeholzer, Steven H.; Fazelinia, Hossein; Singh, Larry N.; Faryabi, Robert B.; Raman, Pichai; Dawany, Noor; Xie, Hongbo Michael; Devkota, Batsal; Diskin, Sharon J.; Anderson, Stewart A.; Rappaport, Eric F.; Peranteau, William; Wikenheiser-Brokamp, Kathryn A.; Teichmann, Sarah; Wallace, Douglas; Peng, Tao; Ding, Yang yang; Kim, Man S.; Xing, Yi; Kong, Sek Won; Bönnemann, Carsten G.; Mandl, Kenneth D.; White, Peter S.

In: Developmental Cell, Vol. 49, No. 1, 08.04.2019, p. 10-29.

Research output: Contribution to journalReview article

Taylor, DM, Aronow, BJ, Tan, K, Bernt, K, Salomonis, N, Greene, CS, Frolova, A, Henrickson, SE, Wells, A, Pei, L, Jaiswal, JK, Whitsett, J, Hamilton, KE, MacParland, SA, Kelsen, J, Heuckeroth, RO, Potter, SS, Vella, LA, Terry, NA, Ghanem, LR, Kennedy, BC, Helbig, I, Sullivan, KE, Castelo-Soccio, L, Kreigstein, A, Herse, F, Nawijn, MC, Koppelman, GH, Haendel, M, Harris, NL, Rokita, JL, Zhang, Y, Regev, A, Rozenblatt-Rosen, O, Rood, JE, Tickle, TL, Vento-Tormo, R, Alimohamed, S, Lek, M, Mar, JC, Loomes, KM, Barrett, DM, Uapinyoying, P, Beggs, AH, Agrawal, PB, Chen, YW, Muir, AB, Garmire, LX, Snapper, SB, Nazarian, J, Seeholzer, SH, Fazelinia, H, Singh, LN, Faryabi, RB, Raman, P, Dawany, N, Xie, HM, Devkota, B, Diskin, SJ, Anderson, SA, Rappaport, EF, Peranteau, W, Wikenheiser-Brokamp, KA, Teichmann, S, Wallace, D, Peng, T, Ding, YY, Kim, MS, Xing, Y, Kong, SW, Bönnemann, CG, Mandl, KD & White, PS 2019, 'The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution', Developmental Cell, vol. 49, no. 1, pp. 10-29. https://doi.org/10.1016/j.devcel.2019.03.001
Taylor, Deanne M. ; Aronow, Bruce J. ; Tan, Kai ; Bernt, Kathrin ; Salomonis, Nathan ; Greene, Casey S. ; Frolova, Alina ; Henrickson, Sarah E. ; Wells, Andrew ; Pei, Liming ; Jaiswal, Jyoti K. ; Whitsett, Jeffrey ; Hamilton, Kathryn E. ; MacParland, Sonya A. ; Kelsen, Judith ; Heuckeroth, Robert O. ; Potter, S. Steven ; Vella, Laura A. ; Terry, Natalie A. ; Ghanem, Louis R. ; Kennedy, Benjamin C. ; Helbig, Ingo ; Sullivan, Kathleen E. ; Castelo-Soccio, Leslie ; Kreigstein, Arnold ; Herse, Florian ; Nawijn, Martijn C. ; Koppelman, Gerard H. ; Haendel, Melissa ; Harris, Nomi L. ; Rokita, Jo Lynne ; Zhang, Yuanchao ; Regev, Aviv ; Rozenblatt-Rosen, Orit ; Rood, Jennifer E. ; Tickle, Timothy L. ; Vento-Tormo, Roser ; Alimohamed, Saif ; Lek, Monkol ; Mar, Jessica C. ; Loomes, Kathleen M. ; Barrett, David M. ; Uapinyoying, Prech ; Beggs, Alan H. ; Agrawal, Pankaj B. ; Chen, Yi Wen ; Muir, Amanda B. ; Garmire, Lana X. ; Snapper, Scott B. ; Nazarian, Javad ; Seeholzer, Steven H. ; Fazelinia, Hossein ; Singh, Larry N. ; Faryabi, Robert B. ; Raman, Pichai ; Dawany, Noor ; Xie, Hongbo Michael ; Devkota, Batsal ; Diskin, Sharon J. ; Anderson, Stewart A. ; Rappaport, Eric F. ; Peranteau, William ; Wikenheiser-Brokamp, Kathryn A. ; Teichmann, Sarah ; Wallace, Douglas ; Peng, Tao ; Ding, Yang yang ; Kim, Man S. ; Xing, Yi ; Kong, Sek Won ; Bönnemann, Carsten G. ; Mandl, Kenneth D. ; White, Peter S. / The Pediatric Cell Atlas : Defining the Growth Phase of Human Development at Single-Cell Resolution. In: Developmental Cell. 2019 ; Vol. 49, No. 1. pp. 10-29.
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AU - Kim, Man S.

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