The omega-3 index: From biomarker to risk marker to risk factor

William Harris

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Blood levels of omega-3 fatty acids reflect the interplay of metabolism and the intake of omega-3-rich foods (eg, oily fish). Multiple lines of evidence link reduced tissue and/or blood levels of omega-3 fatty acids, as reflected in the erythrocyte eicosapentaenoic acid plus docosahexaenoic acid level (ie, the omega-3 index), with increased risk for coronary heart disease, especially sudden cardiac death. The purpose of this review is to examine the extent to which biomarkers like the omega-3 index qualify as coronary heart disease risk markers and/or risk factors based on new criteria from the American Heart Association and older guidelines proposed in 1965 by Sir Austin Bradford Hill. These standards include consistency, strength of association, biological plausibility, coherence, dose-response relationship, clinical utility, cost effectiveness, and prospective validation. The omega-3 index appears to fulfill many of the requirements for a risk marker and, more importantly, for a risk factor.

Original languageEnglish (US)
Pages (from-to)411-417
Number of pages7
JournalCurrent Atherosclerosis Reports
Volume11
Issue number6
DOIs
StatePublished - Nov 2009
Externally publishedYes

Fingerprint

Biomarkers
Omega-3 Fatty Acids
Coronary Disease
Eicosapentaenoic Acid
Docosahexaenoic Acids
Sudden Cardiac Death
Cost-Benefit Analysis
Fishes
Erythrocytes
Guidelines
Food
austin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The omega-3 index : From biomarker to risk marker to risk factor. / Harris, William.

In: Current Atherosclerosis Reports, Vol. 11, No. 6, 11.2009, p. 411-417.

Research output: Contribution to journalArticle

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