The obstetric origins of health for a lifetime

David J.P. Barker, Kent L. Thornburg

    Research output: Contribution to journalReview articlepeer-review

    186 Scopus citations


    There is a new "developmental" model for the origins of a wide range of chronic diseases. Under this model the causes to be identified are linked to normal variations in fetoplacental development. These variations are thought to lead to variations in the supply of nutrients to the baby that permanently alter gene expression, a process known as "programming." According to the developmental model variations in the processes of development program the function of a few key systems that are linked to disease, including the immune system, antioxidant defenses, inflammatory responses, and the number and quality of stem cells.

    Original languageEnglish (US)
    Pages (from-to)511-519
    Number of pages9
    JournalClinical obstetrics and gynecology
    Issue number3
    StatePublished - Sep 1 2013


    • fetal programming
    • maternal nutrition
    • placenta

    ASJC Scopus subject areas

    • Obstetrics and Gynecology


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