The obstetric origins of health for a lifetime

David J.P. Barker; Kent L. Thornburg

doi:10.1097/GRF.0b013e31829cb9ca

The obstetric origins of health for a lifetime

David J.P. Barker, Kent L. Thornburg

Research output: Contribution to journal › Review article › peer-review

186 Scopus citations

Abstract

There is a new "developmental" model for the origins of a wide range of chronic diseases. Under this model the causes to be identified are linked to normal variations in fetoplacental development. These variations are thought to lead to variations in the supply of nutrients to the baby that permanently alter gene expression, a process known as "programming." According to the developmental model variations in the processes of development program the function of a few key systems that are linked to disease, including the immune system, antioxidant defenses, inflammatory responses, and the number and quality of stem cells.

Original language	English (US)
Pages (from-to)	511-519
Number of pages	9
Journal	Clinical obstetrics and gynecology
Volume	56
Issue number	3
DOIs	https://doi.org/10.1097/GRF.0b013e31829cb9ca
State	Published - Sep 1 2013

Keywords

fetal programming
maternal nutrition
placenta

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1097/GRF.0b013e31829cb9ca

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AB - There is a new "developmental" model for the origins of a wide range of chronic diseases. Under this model the causes to be identified are linked to normal variations in fetoplacental development. These variations are thought to lead to variations in the supply of nutrients to the baby that permanently alter gene expression, a process known as "programming." According to the developmental model variations in the processes of development program the function of a few key systems that are linked to disease, including the immune system, antioxidant defenses, inflammatory responses, and the number and quality of stem cells.

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The obstetric origins of health for a lifetime

Abstract

Keywords

ASJC Scopus subject areas

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