The obstetric origins of health for a lifetime

David J P Barker, Kent Thornburg

    Research output: Contribution to journalArticle

    106 Citations (Scopus)

    Abstract

    There is a new "developmental" model for the origins of a wide range of chronic diseases. Under this model the causes to be identified are linked to normal variations in fetoplacental development. These variations are thought to lead to variations in the supply of nutrients to the baby that permanently alter gene expression, a process known as "programming." According to the developmental model variations in the processes of development program the function of a few key systems that are linked to disease, including the immune system, antioxidant defenses, inflammatory responses, and the number and quality of stem cells.

    Original languageEnglish (US)
    Pages (from-to)511-519
    Number of pages9
    JournalClinical Obstetrics and Gynecology
    Volume56
    Issue number3
    DOIs
    StatePublished - Sep 2013

    Fingerprint

    Immune System Diseases
    Obstetrics
    Chronic Disease
    Stem Cells
    Antioxidants
    Gene Expression
    Food
    Health

    Keywords

    • fetal programming
    • maternal nutrition
    • placenta

    ASJC Scopus subject areas

    • Obstetrics and Gynecology

    Cite this

    The obstetric origins of health for a lifetime. / Barker, David J P; Thornburg, Kent.

    In: Clinical Obstetrics and Gynecology, Vol. 56, No. 3, 09.2013, p. 511-519.

    Research output: Contribution to journalArticle

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