The nature and identification of quantitative trait loci: A community's view

Oduola Abiola, Joe M. Angel, Philip Avner, Alexander A. Bachmanov, John Belknap, Beth Bennett, Elizabeth P. Blankenhorn, David A. Blizard, Valerie Bolivar, Gudrun A. Brockmann, Kari Buck, Jean Francois Bureau, William L. Casley, Elissa J. Chesler, James M. Cheverud, Gary A. Churchill, Melloni Cook, John Jr Crabbe, Wim E. Crusio, Ariel DarvasiGerald de Haan, Peter Demant, R. W. Doerge, Rosemary W. Elliott, Charles R. Farber, Lorraine Flaherty, Jonathan Flint, Howard Gershenfeld, John P. Gibson, Jing Gu, Weikuan Gu, Heinz Himmelbauer, Robert Hitzemann, Hui Chen Hsu, Kent Hunter, Fuad A. Iraqi, Ritsert C. Jansen, Thomas E. Johnson, Byron C. Jones, Gerd Kempermann, Frank Lammert, Lu Lu, Kenneth F. Manly, Douglas B. Matthews, Juan F. Medrano, Margarete Mehrabian, Guy Mittleman, Beverly A. Mock, Jeffrey S. Mogil, Xavier Montagutelli, Grant Morahan, John D. Mountz, Hiroki Nagase, Richard S. Nowakowski, Bruce F. O'Hara, Alexander V. Osadchuk, Beverly Paigen, Abraham A. Palmer, Jeremy L. Peirce, Daniel Pomp, Michael Rosemann, Glenn D. Rosen, Leonard C. Schalkwyk, Ze'ev Seltzer, Stephen Settle, Kazuhiro Shimomura, Siming Shou, James M. Sikela, Linda D. Siracusa, Jimmy L. Spearow, Cory Teuscher, David W. Threadgill, Linda A. Toth, Ayo A. Toye, Csaba Vadasz, Gary Van Zant, Edward Wakeland, Robert W. Williams, Huang Ge Zhang, Fei Zou

Research output: Contribution to journalArticle

291 Citations (Scopus)

Abstract

This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?

Original languageEnglish (US)
Pages (from-to)911-916
Number of pages6
JournalNature Reviews Genetics
Volume4
Issue number11
DOIs
StatePublished - Nov 2003

Fingerprint

Quantitative Trait Loci
quantitative trait loci
Genetic Loci
loci
testing

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)

Cite this

Abiola, O., Angel, J. M., Avner, P., Bachmanov, A. A., Belknap, J., Bennett, B., ... Zou, F. (2003). The nature and identification of quantitative trait loci: A community's view. Nature Reviews Genetics, 4(11), 911-916. https://doi.org/10.1038/nrg1206

The nature and identification of quantitative trait loci : A community's view. / Abiola, Oduola; Angel, Joe M.; Avner, Philip; Bachmanov, Alexander A.; Belknap, John; Bennett, Beth; Blankenhorn, Elizabeth P.; Blizard, David A.; Bolivar, Valerie; Brockmann, Gudrun A.; Buck, Kari; Bureau, Jean Francois; Casley, William L.; Chesler, Elissa J.; Cheverud, James M.; Churchill, Gary A.; Cook, Melloni; Crabbe, John Jr; Crusio, Wim E.; Darvasi, Ariel; de Haan, Gerald; Demant, Peter; Doerge, R. W.; Elliott, Rosemary W.; Farber, Charles R.; Flaherty, Lorraine; Flint, Jonathan; Gershenfeld, Howard; Gibson, John P.; Gu, Jing; Gu, Weikuan; Himmelbauer, Heinz; Hitzemann, Robert; Hsu, Hui Chen; Hunter, Kent; Iraqi, Fuad A.; Jansen, Ritsert C.; Johnson, Thomas E.; Jones, Byron C.; Kempermann, Gerd; Lammert, Frank; Lu, Lu; Manly, Kenneth F.; Matthews, Douglas B.; Medrano, Juan F.; Mehrabian, Margarete; Mittleman, Guy; Mock, Beverly A.; Mogil, Jeffrey S.; Montagutelli, Xavier; Morahan, Grant; Mountz, John D.; Nagase, Hiroki; Nowakowski, Richard S.; O'Hara, Bruce F.; Osadchuk, Alexander V.; Paigen, Beverly; Palmer, Abraham A.; Peirce, Jeremy L.; Pomp, Daniel; Rosemann, Michael; Rosen, Glenn D.; Schalkwyk, Leonard C.; Seltzer, Ze'ev; Settle, Stephen; Shimomura, Kazuhiro; Shou, Siming; Sikela, James M.; Siracusa, Linda D.; Spearow, Jimmy L.; Teuscher, Cory; Threadgill, David W.; Toth, Linda A.; Toye, Ayo A.; Vadasz, Csaba; Van Zant, Gary; Wakeland, Edward; Williams, Robert W.; Zhang, Huang Ge; Zou, Fei.

In: Nature Reviews Genetics, Vol. 4, No. 11, 11.2003, p. 911-916.

Research output: Contribution to journalArticle

Abiola, O, Angel, JM, Avner, P, Bachmanov, AA, Belknap, J, Bennett, B, Blankenhorn, EP, Blizard, DA, Bolivar, V, Brockmann, GA, Buck, K, Bureau, JF, Casley, WL, Chesler, EJ, Cheverud, JM, Churchill, GA, Cook, M, Crabbe, JJ, Crusio, WE, Darvasi, A, de Haan, G, Demant, P, Doerge, RW, Elliott, RW, Farber, CR, Flaherty, L, Flint, J, Gershenfeld, H, Gibson, JP, Gu, J, Gu, W, Himmelbauer, H, Hitzemann, R, Hsu, HC, Hunter, K, Iraqi, FA, Jansen, RC, Johnson, TE, Jones, BC, Kempermann, G, Lammert, F, Lu, L, Manly, KF, Matthews, DB, Medrano, JF, Mehrabian, M, Mittleman, G, Mock, BA, Mogil, JS, Montagutelli, X, Morahan, G, Mountz, JD, Nagase, H, Nowakowski, RS, O'Hara, BF, Osadchuk, AV, Paigen, B, Palmer, AA, Peirce, JL, Pomp, D, Rosemann, M, Rosen, GD, Schalkwyk, LC, Seltzer, Z, Settle, S, Shimomura, K, Shou, S, Sikela, JM, Siracusa, LD, Spearow, JL, Teuscher, C, Threadgill, DW, Toth, LA, Toye, AA, Vadasz, C, Van Zant, G, Wakeland, E, Williams, RW, Zhang, HG & Zou, F 2003, 'The nature and identification of quantitative trait loci: A community's view', Nature Reviews Genetics, vol. 4, no. 11, pp. 911-916. https://doi.org/10.1038/nrg1206
Abiola O, Angel JM, Avner P, Bachmanov AA, Belknap J, Bennett B et al. The nature and identification of quantitative trait loci: A community's view. Nature Reviews Genetics. 2003 Nov;4(11):911-916. https://doi.org/10.1038/nrg1206
Abiola, Oduola ; Angel, Joe M. ; Avner, Philip ; Bachmanov, Alexander A. ; Belknap, John ; Bennett, Beth ; Blankenhorn, Elizabeth P. ; Blizard, David A. ; Bolivar, Valerie ; Brockmann, Gudrun A. ; Buck, Kari ; Bureau, Jean Francois ; Casley, William L. ; Chesler, Elissa J. ; Cheverud, James M. ; Churchill, Gary A. ; Cook, Melloni ; Crabbe, John Jr ; Crusio, Wim E. ; Darvasi, Ariel ; de Haan, Gerald ; Demant, Peter ; Doerge, R. W. ; Elliott, Rosemary W. ; Farber, Charles R. ; Flaherty, Lorraine ; Flint, Jonathan ; Gershenfeld, Howard ; Gibson, John P. ; Gu, Jing ; Gu, Weikuan ; Himmelbauer, Heinz ; Hitzemann, Robert ; Hsu, Hui Chen ; Hunter, Kent ; Iraqi, Fuad A. ; Jansen, Ritsert C. ; Johnson, Thomas E. ; Jones, Byron C. ; Kempermann, Gerd ; Lammert, Frank ; Lu, Lu ; Manly, Kenneth F. ; Matthews, Douglas B. ; Medrano, Juan F. ; Mehrabian, Margarete ; Mittleman, Guy ; Mock, Beverly A. ; Mogil, Jeffrey S. ; Montagutelli, Xavier ; Morahan, Grant ; Mountz, John D. ; Nagase, Hiroki ; Nowakowski, Richard S. ; O'Hara, Bruce F. ; Osadchuk, Alexander V. ; Paigen, Beverly ; Palmer, Abraham A. ; Peirce, Jeremy L. ; Pomp, Daniel ; Rosemann, Michael ; Rosen, Glenn D. ; Schalkwyk, Leonard C. ; Seltzer, Ze'ev ; Settle, Stephen ; Shimomura, Kazuhiro ; Shou, Siming ; Sikela, James M. ; Siracusa, Linda D. ; Spearow, Jimmy L. ; Teuscher, Cory ; Threadgill, David W. ; Toth, Linda A. ; Toye, Ayo A. ; Vadasz, Csaba ; Van Zant, Gary ; Wakeland, Edward ; Williams, Robert W. ; Zhang, Huang Ge ; Zou, Fei. / The nature and identification of quantitative trait loci : A community's view. In: Nature Reviews Genetics. 2003 ; Vol. 4, No. 11. pp. 911-916.
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