TY - JOUR
T1 - The N-methyl-D-aspartate receptor subunit NR2B
T2 - Localization, functional properties, regulation, and clinical implications
AU - Loftis, Jennifer M.
AU - Janowsky, Aaron
PY - 2003/1/1
Y1 - 2003/1/1
N2 - The N-methyl-D-aspartate (NMDA) receptor is an example of a heteromeric ligand-gated ion channel that interacts with multiple intracellular proteins by way of different subunits. NMDA receptors are composed of seven known subunits (NR1, NR2A-D, NR3A-B). The present review focuses on the NR2B subunit of the receptor. Over the last several years, an increasing number of reports have demonstrated the importance of the NR2B subunit in a variety of synaptic signaling events and protein-protein interactions. The NR2B subunit has been implicated in modulating functions such as learning, memory processing, pain perception, and feeding behaviors, as well as being involved in a number of human disorders. The following review provides a summary of recent findings regarding the structural features, localization, functional properties, and regulation of the NR2B subunit. The review concludes with a section discussing the role of NR2B in human diseases.
AB - The N-methyl-D-aspartate (NMDA) receptor is an example of a heteromeric ligand-gated ion channel that interacts with multiple intracellular proteins by way of different subunits. NMDA receptors are composed of seven known subunits (NR1, NR2A-D, NR3A-B). The present review focuses on the NR2B subunit of the receptor. Over the last several years, an increasing number of reports have demonstrated the importance of the NR2B subunit in a variety of synaptic signaling events and protein-protein interactions. The NR2B subunit has been implicated in modulating functions such as learning, memory processing, pain perception, and feeding behaviors, as well as being involved in a number of human disorders. The following review provides a summary of recent findings regarding the structural features, localization, functional properties, and regulation of the NR2B subunit. The review concludes with a section discussing the role of NR2B in human diseases.
KW - Cytoskeleton
KW - Excitotoxicity
KW - Glutamate
KW - Kinase
KW - Postsynaptic density
KW - Synaptic plasticity
UR - http://www.scopus.com/inward/record.url?scp=0037216407&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037216407&partnerID=8YFLogxK
U2 - 10.1016/S0163-7258(02)00302-9
DO - 10.1016/S0163-7258(02)00302-9
M3 - Review article
C2 - 12493535
AN - SCOPUS:0037216407
SN - 0163-7258
VL - 97
SP - 55
EP - 85
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
IS - 1
ER -