The murine T-cell receptor uses a limited repertoire of expressed V β gene segments

Richard K. Barth, Byung S. Kim, Nancy C. Lan, Tim Hunkapiller, Nancy Sobieck, Astar Winoto, Howard Gershenfeld, Craig Okada, Dan Hansburg, Irving L. Weissman, Leroy Hood

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208 Scopus citations

Abstract

Only 10 different Vβ gene segments were found when the sequences of 15 variable (Vβ) genes of the mouse T-cell receptor were examined. From this analysis we calculate that the total number of expressed Vβ gene segments may be 21 or fewer, which makes the expressed germline Vβ repertoire much smaller than that of the immunoglobulin heavy-chain or light-chain genes. We suggest that βchain somatic diversification is concentrated at the Vβ-D β-Jβ junctions.

Original languageEnglish (US)
Pages (from-to)517-523
Number of pages7
JournalNature
Volume316
Issue number6028
DOIs
StatePublished - Dec 1 1985

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    Barth, R. K., Kim, B. S., Lan, N. C., Hunkapiller, T., Sobieck, N., Winoto, A., Gershenfeld, H., Okada, C., Hansburg, D., Weissman, I. L., & Hood, L. (1985). The murine T-cell receptor uses a limited repertoire of expressed V β gene segments. Nature, 316(6028), 517-523. https://doi.org/10.1038/316517a0