The mouse mutation sarcosinemia (sar) maps to chromosome 2 in a region homologous to human 9q33-q34

Ana Lúcia Bueno Brunialti, Cary Harding, Jon A. Wolff, Jean Louis Guénet

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The autosomal recessive mouse mutation sarcosinemia (sar), which was discovered segregating in the progeny of a male whose premeiotic germ cells had been treated with the mutagen ethylnitrosourea, is characterized by a deficiency in sarcosine dehydrogenase activity. Using an intersubspecific cross, we mapped the sar locus to mouse chromosome 2, approximately 15-18 cM from the centromere. The genetic localization of this locus in the mouse allows the identification of a candidate region in human (9q33-q34) where the homologous disease should map.

Original languageEnglish (US)
Pages (from-to)182-184
Number of pages3
JournalGenomics
Volume36
Issue number1
DOIs
StatePublished - Aug 15 1996
Externally publishedYes

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Chromosomes, Human, Pair 2
Sarcosine Dehydrogenase
Mutation
Ethylnitrosourea
Genetic Loci
Centromere
Mutagens
Germ Cells
Sarcosinemia

ASJC Scopus subject areas

  • Genetics

Cite this

The mouse mutation sarcosinemia (sar) maps to chromosome 2 in a region homologous to human 9q33-q34. / Bueno Brunialti, Ana Lúcia; Harding, Cary; Wolff, Jon A.; Guénet, Jean Louis.

In: Genomics, Vol. 36, No. 1, 15.08.1996, p. 182-184.

Research output: Contribution to journalArticle

Bueno Brunialti, Ana Lúcia ; Harding, Cary ; Wolff, Jon A. ; Guénet, Jean Louis. / The mouse mutation sarcosinemia (sar) maps to chromosome 2 in a region homologous to human 9q33-q34. In: Genomics. 1996 ; Vol. 36, No. 1. pp. 182-184.
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