The mouse mutation sarcosinemia (sar) maps to chromosome 2 in a region homologous to human 9q33-q34

Ana Lúcia Bueno Brunialti, Cary O. Harding, Jon A. Wolff, Jean Louis Guénet

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The autosomal recessive mouse mutation sarcosinemia (sar), which was discovered segregating in the progeny of a male whose premeiotic germ cells had been treated with the mutagen ethylnitrosourea, is characterized by a deficiency in sarcosine dehydrogenase activity. Using an intersubspecific cross, we mapped the sar locus to mouse chromosome 2, approximately 15-18 cM from the centromere. The genetic localization of this locus in the mouse allows the identification of a candidate region in human (9q33-q34) where the homologous disease should map.

Original languageEnglish (US)
Pages (from-to)182-184
Number of pages3
JournalGenomics
Volume36
Issue number1
DOIs
StatePublished - Aug 15 1996

ASJC Scopus subject areas

  • Genetics

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