The mouse mutation sarcosinemia (sar) maps to chromosome 2 in a region homologous to human 9q33-q34

Ana Lúcia Bueno Brunialti; Cary O. Harding; Jon A. Wolff; Jean Louis Guénet

doi:10.1006/geno.1996.0442

The mouse mutation sarcosinemia (sar) maps to chromosome 2 in a region homologous to human 9q33-q34

Ana Lúcia Bueno Brunialti, Cary O. Harding, Jon A. Wolff, Jean Louis Guénet

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The autosomal recessive mouse mutation sarcosinemia (sar), which was discovered segregating in the progeny of a male whose premeiotic germ cells had been treated with the mutagen ethylnitrosourea, is characterized by a deficiency in sarcosine dehydrogenase activity. Using an intersubspecific cross, we mapped the sar locus to mouse chromosome 2, approximately 15-18 cM from the centromere. The genetic localization of this locus in the mouse allows the identification of a candidate region in human (9q33-q34) where the homologous disease should map.

Original language	English (US)
Pages (from-to)	182-184
Number of pages	3
Journal	Genomics
Volume	36
Issue number	1
DOIs	https://doi.org/10.1006/geno.1996.0442
State	Published - Aug 15 1996
Externally published	Yes

ASJC Scopus subject areas

Genetics

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title = "The mouse mutation sarcosinemia (sar) maps to chromosome 2 in a region homologous to human 9q33-q34",

abstract = "The autosomal recessive mouse mutation sarcosinemia (sar), which was discovered segregating in the progeny of a male whose premeiotic germ cells had been treated with the mutagen ethylnitrosourea, is characterized by a deficiency in sarcosine dehydrogenase activity. Using an intersubspecific cross, we mapped the sar locus to mouse chromosome 2, approximately 15-18 cM from the centromere. The genetic localization of this locus in the mouse allows the identification of a candidate region in human (9q33-q34) where the homologous disease should map.",

author = "{Bueno Brunialti}, {Ana L{\'u}cia} and Harding, {Cary O.} and Wolff, {Jon A.} and Gu{\'e}net, {Jean Louis}",

note = "Funding Information: A.L.B.B. is the recipient of a fellowship from the Association Fran-c{\"E}aise contre les Myopathies (AFM). This work was supported, in France, by grants from the Association Franc{\"E}aise contre les Myopathies (AFM) and the Groupement de Recherches et d'Etudes sur les Ge{\^A}nomes (GREG). The authors thank D. Chang for her assistance with urine paper chromatography.",

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AU - Wolff, Jon A.

AU - Guénet, Jean Louis

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AB - The autosomal recessive mouse mutation sarcosinemia (sar), which was discovered segregating in the progeny of a male whose premeiotic germ cells had been treated with the mutagen ethylnitrosourea, is characterized by a deficiency in sarcosine dehydrogenase activity. Using an intersubspecific cross, we mapped the sar locus to mouse chromosome 2, approximately 15-18 cM from the centromere. The genetic localization of this locus in the mouse allows the identification of a candidate region in human (9q33-q34) where the homologous disease should map.

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The mouse mutation sarcosinemia (sar) maps to chromosome 2 in a region homologous to human 9q33-q34

Abstract

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