The mitochondrial permeability transition from in vitro artifact to disease target

Paolo Bernardi, Alexandra Krauskopf, Emy Basso, Valeria Petronilli, Elizabeth Blalchy-Dyson, Fabio Di Lisa, Michael Forte

Research output: Contribution to journalArticle

485 Citations (Scopus)

Abstract

The mitochondrial permeability transition pore is a high conductance channel whose opening leads to an increase of mitochondrial inner membrane permeability to solutes with molecular masses up to ≈1500 Da. In this review we trace the rise of the permeability transition pore from the status of in vitro artifact to that of effector mechanism of cell death. We then cover recent results based on genetic inactivation of putative permeability transition pore components, and discuss their meaning for our understanding of pore structure. Finally, we discuss evidence indicating that the permeability transition pore plays a role in pathophysiology, with specific emphasis on in vivo models of disease.

Original languageEnglish (US)
Pages (from-to)2077-2099
Number of pages23
JournalFEBS Journal
Volume273
Issue number10
DOIs
StatePublished - May 2006

Fingerprint

Molecular mass
Cell death
Pore structure
Artifacts
Permeability
Membranes
Mitochondrial Membranes
Cell Death
mitochondrial permeability transition pore
In Vitro Techniques

Keywords

  • Apoptosis
  • Calcium
  • Cancer
  • Cell death
  • Degenerative diseases
  • Drugs
  • Mitochondria
  • Necrosis
  • Permeability transition

ASJC Scopus subject areas

  • Biochemistry

Cite this

Bernardi, P., Krauskopf, A., Basso, E., Petronilli, V., Blalchy-Dyson, E., Di Lisa, F., & Forte, M. (2006). The mitochondrial permeability transition from in vitro artifact to disease target. FEBS Journal, 273(10), 2077-2099. https://doi.org/10.1111/j.1742-4658.2006.05213.x

The mitochondrial permeability transition from in vitro artifact to disease target. / Bernardi, Paolo; Krauskopf, Alexandra; Basso, Emy; Petronilli, Valeria; Blalchy-Dyson, Elizabeth; Di Lisa, Fabio; Forte, Michael.

In: FEBS Journal, Vol. 273, No. 10, 05.2006, p. 2077-2099.

Research output: Contribution to journalArticle

Bernardi, P, Krauskopf, A, Basso, E, Petronilli, V, Blalchy-Dyson, E, Di Lisa, F & Forte, M 2006, 'The mitochondrial permeability transition from in vitro artifact to disease target', FEBS Journal, vol. 273, no. 10, pp. 2077-2099. https://doi.org/10.1111/j.1742-4658.2006.05213.x
Bernardi P, Krauskopf A, Basso E, Petronilli V, Blalchy-Dyson E, Di Lisa F et al. The mitochondrial permeability transition from in vitro artifact to disease target. FEBS Journal. 2006 May;273(10):2077-2099. https://doi.org/10.1111/j.1742-4658.2006.05213.x
Bernardi, Paolo ; Krauskopf, Alexandra ; Basso, Emy ; Petronilli, Valeria ; Blalchy-Dyson, Elizabeth ; Di Lisa, Fabio ; Forte, Michael. / The mitochondrial permeability transition from in vitro artifact to disease target. In: FEBS Journal. 2006 ; Vol. 273, No. 10. pp. 2077-2099.
@article{deabb87f1cbf421eaa0f16a488023a41,
title = "The mitochondrial permeability transition from in vitro artifact to disease target",
abstract = "The mitochondrial permeability transition pore is a high conductance channel whose opening leads to an increase of mitochondrial inner membrane permeability to solutes with molecular masses up to ≈1500 Da. In this review we trace the rise of the permeability transition pore from the status of in vitro artifact to that of effector mechanism of cell death. We then cover recent results based on genetic inactivation of putative permeability transition pore components, and discuss their meaning for our understanding of pore structure. Finally, we discuss evidence indicating that the permeability transition pore plays a role in pathophysiology, with specific emphasis on in vivo models of disease.",
keywords = "Apoptosis, Calcium, Cancer, Cell death, Degenerative diseases, Drugs, Mitochondria, Necrosis, Permeability transition",
author = "Paolo Bernardi and Alexandra Krauskopf and Emy Basso and Valeria Petronilli and Elizabeth Blalchy-Dyson and {Di Lisa}, Fabio and Michael Forte",
year = "2006",
month = "5",
doi = "10.1111/j.1742-4658.2006.05213.x",
language = "English (US)",
volume = "273",
pages = "2077--2099",
journal = "FEBS Journal",
issn = "1742-464X",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - The mitochondrial permeability transition from in vitro artifact to disease target

AU - Bernardi, Paolo

AU - Krauskopf, Alexandra

AU - Basso, Emy

AU - Petronilli, Valeria

AU - Blalchy-Dyson, Elizabeth

AU - Di Lisa, Fabio

AU - Forte, Michael

PY - 2006/5

Y1 - 2006/5

N2 - The mitochondrial permeability transition pore is a high conductance channel whose opening leads to an increase of mitochondrial inner membrane permeability to solutes with molecular masses up to ≈1500 Da. In this review we trace the rise of the permeability transition pore from the status of in vitro artifact to that of effector mechanism of cell death. We then cover recent results based on genetic inactivation of putative permeability transition pore components, and discuss their meaning for our understanding of pore structure. Finally, we discuss evidence indicating that the permeability transition pore plays a role in pathophysiology, with specific emphasis on in vivo models of disease.

AB - The mitochondrial permeability transition pore is a high conductance channel whose opening leads to an increase of mitochondrial inner membrane permeability to solutes with molecular masses up to ≈1500 Da. In this review we trace the rise of the permeability transition pore from the status of in vitro artifact to that of effector mechanism of cell death. We then cover recent results based on genetic inactivation of putative permeability transition pore components, and discuss their meaning for our understanding of pore structure. Finally, we discuss evidence indicating that the permeability transition pore plays a role in pathophysiology, with specific emphasis on in vivo models of disease.

KW - Apoptosis

KW - Calcium

KW - Cancer

KW - Cell death

KW - Degenerative diseases

KW - Drugs

KW - Mitochondria

KW - Necrosis

KW - Permeability transition

UR - http://www.scopus.com/inward/record.url?scp=33646255246&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646255246&partnerID=8YFLogxK

U2 - 10.1111/j.1742-4658.2006.05213.x

DO - 10.1111/j.1742-4658.2006.05213.x

M3 - Article

C2 - 16649987

AN - SCOPUS:33646255246

VL - 273

SP - 2077

EP - 2099

JO - FEBS Journal

JF - FEBS Journal

SN - 1742-464X

IS - 10

ER -