The metabotropic glutamate receptors: Structure and functions

J. P. Pin, R. Duvoisin

Research output: Contribution to journalReview article

845 Scopus citations

Abstract

Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels-termed NMDA, AMPA and kainate receptors-involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins. The existence of these receptors, called metabotropic glutamate receptors, is changing our views on the functioning of fast excitatory synapses.

Original languageEnglish (US)
Pages (from-to)1-26
Number of pages26
JournalNeuropharmacology
Volume34
Issue number1
DOIs
StatePublished - Jan 1995

Keywords

  • ACPD
  • Ca-channels
  • G-protein
  • K-channels
  • LTD
  • LTP
  • PLC
  • adenylyl cyclase
  • alternative splicing
  • cloning
  • glutamate
  • mGluR

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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