The metabotropic glutamate receptors

Structure and functions

J. P. Pin, Robert Duvoisin

Research output: Contribution to journalArticle

824 Citations (Scopus)

Abstract

Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels-termed NMDA, AMPA and kainate receptors-involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins. The existence of these receptors, called metabotropic glutamate receptors, is changing our views on the functioning of fast excitatory synapses.

Original languageEnglish (US)
Pages (from-to)1-26
Number of pages26
JournalNeuropharmacology
Volume34
Issue number1
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Metabotropic Glutamate Receptors
Glutamic Acid
Ligand-Gated Ion Channels
Kainic Acid Receptors
AMPA Receptors
Second Messenger Systems
G-Protein-Coupled Receptors
N-Methyl-D-Aspartate Receptors
Ion Channels
Synaptic Transmission
Synapses
Neurotransmitter Agents
Brain
Enzymes

Keywords

  • ACPD
  • adenylyl cyclase
  • alternative splicing
  • Ca-channels
  • cloning
  • G-protein
  • glutamate
  • K-channels
  • LTD
  • LTP
  • mGluR
  • PLC

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology
  • Drug Discovery

Cite this

The metabotropic glutamate receptors : Structure and functions. / Pin, J. P.; Duvoisin, Robert.

In: Neuropharmacology, Vol. 34, No. 1, 1995, p. 1-26.

Research output: Contribution to journalArticle

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