The mechanisms by which growth hormone brings about growth: The relative contributions of growth hormone and insulin-like growth factors

A. Spagnoli, Ronald (Ron) Rosenfeld

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Growth hormone is the major regulator of postnatal growth. Although intrauterine growth seems to be largely growth hormone independent, gene knockout studies have established the pivotal role of the IGF system in both prenatal and postnatal growth. The original 'somatomedin hypothesis' postulated that all of the growth-promoting actions of growth hormone were mediated by IGFs. Several in vitro and in vivo studies have suggested, however, that growth hormone may have specific growth-related actions in addition to stimulating IGF production, including promoting differentiation of prechondrocytes at the growth plate and stimulation of synthesis of proteins involved in IGF transport and clearance. An integrated model of interrelated role(s) of growth hormone and IGF in skeletal growth is proposed.

Original languageEnglish (US)
Pages (from-to)615-631
Number of pages17
JournalEndocrinology and Metabolism Clinics of North America
Volume25
Issue number3
StatePublished - 1996

Fingerprint

Somatomedins
Growth Hormone
Growth
Gene Knockout Techniques
Growth Plate
Genes
Proteins

ASJC Scopus subject areas

  • Endocrinology
  • Biochemistry

Cite this

The mechanisms by which growth hormone brings about growth : The relative contributions of growth hormone and insulin-like growth factors. / Spagnoli, A.; Rosenfeld, Ronald (Ron).

In: Endocrinology and Metabolism Clinics of North America, Vol. 25, No. 3, 1996, p. 615-631.

Research output: Contribution to journalArticle

@article{999fa20217c540b7bc57c95d1c594527,
title = "The mechanisms by which growth hormone brings about growth: The relative contributions of growth hormone and insulin-like growth factors",
abstract = "Growth hormone is the major regulator of postnatal growth. Although intrauterine growth seems to be largely growth hormone independent, gene knockout studies have established the pivotal role of the IGF system in both prenatal and postnatal growth. The original 'somatomedin hypothesis' postulated that all of the growth-promoting actions of growth hormone were mediated by IGFs. Several in vitro and in vivo studies have suggested, however, that growth hormone may have specific growth-related actions in addition to stimulating IGF production, including promoting differentiation of prechondrocytes at the growth plate and stimulation of synthesis of proteins involved in IGF transport and clearance. An integrated model of interrelated role(s) of growth hormone and IGF in skeletal growth is proposed.",
author = "A. Spagnoli and Rosenfeld, {Ronald (Ron)}",
year = "1996",
language = "English (US)",
volume = "25",
pages = "615--631",
journal = "Endocrinology and Metabolism Clinics of North America",
issn = "0889-8529",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - The mechanisms by which growth hormone brings about growth

T2 - The relative contributions of growth hormone and insulin-like growth factors

AU - Spagnoli, A.

AU - Rosenfeld, Ronald (Ron)

PY - 1996

Y1 - 1996

N2 - Growth hormone is the major regulator of postnatal growth. Although intrauterine growth seems to be largely growth hormone independent, gene knockout studies have established the pivotal role of the IGF system in both prenatal and postnatal growth. The original 'somatomedin hypothesis' postulated that all of the growth-promoting actions of growth hormone were mediated by IGFs. Several in vitro and in vivo studies have suggested, however, that growth hormone may have specific growth-related actions in addition to stimulating IGF production, including promoting differentiation of prechondrocytes at the growth plate and stimulation of synthesis of proteins involved in IGF transport and clearance. An integrated model of interrelated role(s) of growth hormone and IGF in skeletal growth is proposed.

AB - Growth hormone is the major regulator of postnatal growth. Although intrauterine growth seems to be largely growth hormone independent, gene knockout studies have established the pivotal role of the IGF system in both prenatal and postnatal growth. The original 'somatomedin hypothesis' postulated that all of the growth-promoting actions of growth hormone were mediated by IGFs. Several in vitro and in vivo studies have suggested, however, that growth hormone may have specific growth-related actions in addition to stimulating IGF production, including promoting differentiation of prechondrocytes at the growth plate and stimulation of synthesis of proteins involved in IGF transport and clearance. An integrated model of interrelated role(s) of growth hormone and IGF in skeletal growth is proposed.

UR - http://www.scopus.com/inward/record.url?scp=0029787471&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029787471&partnerID=8YFLogxK

M3 - Article

C2 - 8879989

AN - SCOPUS:0029787471

VL - 25

SP - 615

EP - 631

JO - Endocrinology and Metabolism Clinics of North America

JF - Endocrinology and Metabolism Clinics of North America

SN - 0889-8529

IS - 3

ER -