TY - JOUR
T1 - The mechanisms by which growth hormone brings about growth
T2 - The relative contributions of growth hormone and insulin-like growth factors
AU - Spagnoli, A.
AU - Rosenfeld, R. G.
N1 - Funding Information:
This work was supported in part by grant CA 58110 from the National Institutes of Health (RGR).
PY - 1996
Y1 - 1996
N2 - Growth hormone is the major regulator of postnatal growth. Although intrauterine growth seems to be largely growth hormone independent, gene knockout studies have established the pivotal role of the IGF system in both prenatal and postnatal growth. The original 'somatomedin hypothesis' postulated that all of the growth-promoting actions of growth hormone were mediated by IGFs. Several in vitro and in vivo studies have suggested, however, that growth hormone may have specific growth-related actions in addition to stimulating IGF production, including promoting differentiation of prechondrocytes at the growth plate and stimulation of synthesis of proteins involved in IGF transport and clearance. An integrated model of interrelated role(s) of growth hormone and IGF in skeletal growth is proposed.
AB - Growth hormone is the major regulator of postnatal growth. Although intrauterine growth seems to be largely growth hormone independent, gene knockout studies have established the pivotal role of the IGF system in both prenatal and postnatal growth. The original 'somatomedin hypothesis' postulated that all of the growth-promoting actions of growth hormone were mediated by IGFs. Several in vitro and in vivo studies have suggested, however, that growth hormone may have specific growth-related actions in addition to stimulating IGF production, including promoting differentiation of prechondrocytes at the growth plate and stimulation of synthesis of proteins involved in IGF transport and clearance. An integrated model of interrelated role(s) of growth hormone and IGF in skeletal growth is proposed.
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U2 - 10.1016/S0889-8529(05)70343-1
DO - 10.1016/S0889-8529(05)70343-1
M3 - Article
C2 - 8879989
AN - SCOPUS:0029787471
SN - 0889-8529
VL - 25
SP - 615
EP - 631
JO - Endocrinology and Metabolism Clinics of North America
JF - Endocrinology and Metabolism Clinics of North America
IS - 3
ER -