The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila

Sylvain Brun, Sheila Vidal, Paul Spellman, Kuniaki Takahashi, Hervé Tricoire, Bruno Lemaitre

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Septic injury triggers a rapid and widespread response in Drosophila adults that involves the upregulation of many genes required to combat infection and for wound healing. Genome-wide expression profiling has already demonstrated that this response is controlled by signaling through the Toll, Imd, JAK-STAT and JNK pathways. Using oligonucleotide microarrays, we now demonstrate that the MAPKKK Mekk1 regulates a small subset of genes induced by septic injury including Turandot (Tot) stress genes. Our analysis indicates that Tot genes show a complex regulation pattern including signals from both the JAK-STAT and Imd pathways and Mekk1. Interestingly, Mekk1 flies are resistant to microbial infection but susceptible to paraquat, an inducer of oxidative stress. These results point to a role of Mekk1 in the protection against tissue damage and/or protein degradation and indicate complex interactions between stress and immune pathways in Drosophila.

Original languageEnglish (US)
Pages (from-to)397-407
Number of pages11
JournalGenes to Cells
Volume11
Issue number4
DOIs
StatePublished - Apr 1 2006

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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