Abstract
Septic injury triggers a rapid and widespread response in Drosophila adults that involves the upregulation of many genes required to combat infection and for wound healing. Genome-wide expression profiling has already demonstrated that this response is controlled by signaling through the Toll, Imd, JAK-STAT and JNK pathways. Using oligonucleotide microarrays, we now demonstrate that the MAPKKK Mekk1 regulates a small subset of genes induced by septic injury including Turandot (Tot) stress genes. Our analysis indicates that Tot genes show a complex regulation pattern including signals from both the JAK-STAT and Imd pathways and Mekk1. Interestingly, Mekk1 flies are resistant to microbial infection but susceptible to paraquat, an inducer of oxidative stress. These results point to a role of Mekk1 in the protection against tissue damage and/or protein degradation and indicate complex interactions between stress and immune pathways in Drosophila.
Original language | English (US) |
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Pages (from-to) | 397-407 |
Number of pages | 11 |
Journal | Genes to Cells |
Volume | 11 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2006 |
Externally published | Yes |
ASJC Scopus subject areas
- Genetics
- Cell Biology