The many important facets of T-cell repertoire diversity

Janko Nikolich-Žugich, Mark K. Slifka, Ilhem Messaoudi

    Research output: Contribution to journalReview articlepeer-review

    453 Scopus citations


    In the thymus, a diverse and polymorphic T-cell repertoire is generated by random recombination of discrete T-cell receptor (TCR)-αβ gene segments. This repertoire is then shaped by intrathymic selection events to generate a peripheral T-cell pool of self-MHC restricted, non-autoaggressive T cells. It has long been postulated that some optimal level of TCR diversity allows efficient protection against pathogens. This article focuses on several recent advances that address the required diversity for the generation of an optimal immune response.

    Original languageEnglish (US)
    Pages (from-to)123-132
    Number of pages10
    JournalNature Reviews Immunology
    Issue number2
    StatePublished - Feb 2004

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology


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