TY - JOUR
T1 - The many faces of REST oversee epigenetic programming of neuronal genes
AU - Ballas, Nurit
AU - Mandel, Gail
N1 - Funding Information:
The authors thank J Chenoweth IV and R Shiekhattar for permitting us to cite unpublished work, and J Speh for help with the figures. We apologize for omitted citations due to space limitations. G Mandel is an investigator of the Howard Hughes Medical Institute. We acknowledge support from a National Institutes of Health grant to G Mandel.
PY - 2005/10
Y1 - 2005/10
N2 - Nervous system development relies on a complex signaling network to engineer the orderly transitions that lead to the acquisition of a neural cell fate. Progression from the non-neuronal pluripotent stem cell to a restricted neural lineage is characterized by distinct patterns of gene expression, particularly the restriction of neuronal gene expression to neurons. Concurrently, cells outside the nervous system acquire and maintain a non-neuronal fate that permanently excludes expression of neuronal genes. Studies of the transcriptional repressor REST, which regulates a large network of neuronal genes, provide a paradigm for elucidating the link between epigenetic mechanisms and neurogenesis. REST orchestrates a set of epigenetic modifications that are distinct between non-neuronal cells that give rise to neurons and those that are destined to remain as nervous system outsiders.
AB - Nervous system development relies on a complex signaling network to engineer the orderly transitions that lead to the acquisition of a neural cell fate. Progression from the non-neuronal pluripotent stem cell to a restricted neural lineage is characterized by distinct patterns of gene expression, particularly the restriction of neuronal gene expression to neurons. Concurrently, cells outside the nervous system acquire and maintain a non-neuronal fate that permanently excludes expression of neuronal genes. Studies of the transcriptional repressor REST, which regulates a large network of neuronal genes, provide a paradigm for elucidating the link between epigenetic mechanisms and neurogenesis. REST orchestrates a set of epigenetic modifications that are distinct between non-neuronal cells that give rise to neurons and those that are destined to remain as nervous system outsiders.
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U2 - 10.1016/j.conb.2005.08.015
DO - 10.1016/j.conb.2005.08.015
M3 - Review article
C2 - 16150588
AN - SCOPUS:25844518743
SN - 0959-4388
VL - 15
SP - 500
EP - 506
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 5
ER -