The long and short of colicin action: The molecular basis for the biological activity of channel-forming colicins

Eric Gouaux

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Channel-forming colicins undergo a remarkable series of conformational gyrations during their voyage from the extracellular milieu to the periplasmic membrane. Crystal structures of the intact colicin la molecule and a channel-forming domain of colicin E1 illuminate relationships between the molecular structure and biological function of these voltage-dependent channel-forming toxins.

Original languageEnglish (US)
Pages (from-to)313-317
Number of pages5
JournalStructure
Volume5
Issue number3
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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