The life cycle of c-Myc: From synthesis to degradation

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239 Scopus citations

Abstract

The c-Myc transcription factor is a potent regulator of cellular proliferation and cell fate decision. Precise regulation of c-Myc protein levels is essential to maintain normal cell function. In order to maintain proper levels of c-Myc, its protein stability is tightly controlled, c-Myc is degraded through the ubiquitin-proteasome pathway. This perspective discusses a sophisticated and complex signaling pathway that controls the life cycle of c-Myc from protein synthesis to ubiquitin-mediated degradation. The pathway involves Ras-activated kinases, the Pin1 prolyl isomerase, the PP2A phosphatase and a series of c-Myc phosphorylation and dephosphorylation events that control its stability.

Original languageEnglish (US)
Pages (from-to)1131-1135
Number of pages5
JournalCell Cycle
Volume3
Issue number9
DOIs
StatePublished - Sep 2004

Keywords

  • ERK
  • GSK-3β
  • PP2A
  • Pin1
  • Ras
  • Serine 62
  • Stability
  • Threonine 58
  • c-Myc

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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