@article{eb66d3dc847c4c0991d9f579cb9e7e92,
title = "The key role of T cells in Parkinson's disease pathogenesis and therapy",
abstract = "This review focuses on the role of T lymphocytes in the pathogenesis of Parkinson's disease and highlights evidence for modulation of the T cell response as an effective neuroprotective strategy. In preclinical models of Parkinson's disease, modulation of the T cell response results in neuroprotection. Peripheral markers of T cell response show changes in Parkinson's patients relative to controls that have potential application as diagnostic and therapeutic biomarkers. The article also discusses the important immunomodulatory effects of dopamine which may confound study of T cells in patients on dopaminergic therapies, and highlights glatiramer acetate, an FDA-approved therapy for multiple sclerosis that works through modulating the T cell response, as a promising target for translation.",
keywords = "Biomarkers, Dopamine, Glatiramer acetate, Immunomodulation, Neuroinflammation, Neuroprotection, Parkinson's disease, Pathogenesis, T cells, T lymphocytes",
author = "Baird, {Jill K.} and Dennis Bourdette and Meshul, {Charles K.} and Quinn, {Joseph F.}",
note = "Funding Information: This work was supported by Merit Review BX 001643 and BX000552 to CKM from the United States (U.S.) Department of Veterans Affairs Biomedical Laboratory Research and Development; Veterans Affairs Northwest Parkinson's Disease Research, Education, and Clinical Care Center (PADRECC)); NINDS 1U10NS077350 (JFQ); The contents do not represent the views of the U.S. Department of Veterans Affairs or the United States Government. Funding Information: This work was supported by Merit Review BX 001643 and BX000552 to CKM from the United States (U.S.) Department of Veterans Affairs Biomedical Laboratory Research and Development ; Veterans Affairs Northwest Parkinson{\textquoteright}s Disease Research, Education, and Clinical Care Center (PADRECC) ); NINDS 1U10NS077350 (JFQ); The contents do not represent the views of the U.S. Department of Veterans Affairs or the United States Government. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2019",
month = mar,
doi = "10.1016/j.parkreldis.2018.10.029",
language = "English (US)",
volume = "60",
pages = "25--31",
journal = "Parkinsonism and Related Disorders",
issn = "1353-8020",
publisher = "Elsevier BV",
}