The insulin-like growth factor system in the prostate

D. M. Peehl, P. Cohen, Ronald (Ron) Rosenfeld

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The insulin-like growth factor (IGF) system is involved in the regulation of cell growth. The system involves a network of molecules that includes the IGFs themselves (IGF-I and -II), IGF receptors (types I and II), IGF-binding proteins (IGFBP-1 through -6), and IGFBP proteases. Characterization of this complex system in the prostate has recently been initiated. Prostatic cell lines as well as primary cultures of prostatic epithelial and stromal cells have been analyzed for expression of IGFs, receptors, and IGFBPs. Prostatic epithelial cells and, quite likely, stromal cells as well respond to the mitogenic activity of IGFs via the type I IGF receptor. Prostatic stromal cells synthesize and secrete IGF-II; there is evidence that prostatic cell lines also synthesize IGFs, but this has not been confirmed in primary cultures of prostatic epithelial cells. Prostatic stromal and epithelial cells secrete a number of IGFBPs. The biological impact of some of these IGFBPs on the growth of prostatic cells has been examined, and proteolytic cleavage of IGFBP-3 by prostate-specific antigen (PSA) has been demonstrated. Aberrations in several elements of the IGF system have been observed in stromal cells derived from benign prostatic hyperplasia (BPH). The IGF system may therefore have a part in the etiology of BPH as well as in normal and malignant processes in the prostate.

Original languageEnglish (US)
Pages (from-to)306-311
Number of pages6
JournalWorld Journal of Urology
Volume13
Issue number5
DOIs
StatePublished - Oct 1995

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Somatomedins
Stromal Cells
Prostate
Insulin-Like Growth Factor Binding Proteins
Epithelial Cells
Insulin-Like Growth Factor Binding Protein 1
Insulin-Like Growth Factor II
Prostatic Hyperplasia
Insulin-Like Growth Factor I
Insulin-Like Growth Factor Binding Protein 6
IGF Type 2 Receptor
Somatomedin Receptors
Cell Line
IGF Type 1 Receptor
Insulin-Like Growth Factor Binding Protein 3
Prostate-Specific Antigen
Growth
Peptide Hydrolases

ASJC Scopus subject areas

  • Urology

Cite this

The insulin-like growth factor system in the prostate. / Peehl, D. M.; Cohen, P.; Rosenfeld, Ronald (Ron).

In: World Journal of Urology, Vol. 13, No. 5, 10.1995, p. 306-311.

Research output: Contribution to journalArticle

Peehl, DM, Cohen, P & Rosenfeld, RR 1995, 'The insulin-like growth factor system in the prostate', World Journal of Urology, vol. 13, no. 5, pp. 306-311. https://doi.org/10.1007/BF00185974
Peehl, D. M. ; Cohen, P. ; Rosenfeld, Ronald (Ron). / The insulin-like growth factor system in the prostate. In: World Journal of Urology. 1995 ; Vol. 13, No. 5. pp. 306-311.
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