The Impact of Therapeutic Antibodies on the Management of Digestive Diseases: History, Current Practice, and Future Directions

Mark (Anthony) Sofia, David T. Rubin

Research output: Contribution to journalEditorialpeer-review

11 Scopus citations

Abstract

The development of therapeutic antibodies represents a revolutionary change in medical therapy for digestive diseases. Beginning with the initial studies that confirmed the pathogenicity of cytokines in inflammatory bowel disease, the development and application of therapeutic antibodies brought challenges and insights into their potential and optimal use. Infliximab was the first biological drug approved for use in Crohn’s disease and ulcerative colitis. The lessons learned from infliximab include the importance of immunogenicity and the influence of pharmacokinetics on disease response and outcomes. Building on this foundation, other therapeutic antibodies achieved approval for inflammatory bowel disease and many more are in development for several digestive diseases. In this review, we reflect on the history of therapeutic antibodies and discuss current practice and future directions for the field.

Original languageEnglish (US)
Pages (from-to)833-842
Number of pages10
JournalDigestive diseases and sciences
Volume62
Issue number4
DOIs
StatePublished - Apr 1 2017
Externally publishedYes

Keywords

  • Adalimumab
  • Inflammatory bowel disease
  • Infliximab
  • Therapeutic antibodies
  • Therapeutic drug monitoring
  • Tumor necrosis factor alpha

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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