The impact of age, body mass index, and fish intake on the EPA and DHA content of human erythrocytes

Scott A. Sands, Kimberly J. Reid, Sheryl L. Windsor, William Harris

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

n-3 FA are beneficial for cardiovascular health, reducing platelet aggregation, TG levels, and the risk of sudden death from myocardial infarction. The percentage of EPA + DHA in red blood cells (RBC), also known as the Omega-3 Index, has recently been proposed as a risk marker for death from coronary heart disease (CHD). The purpose of this study was to begin to explore the factors that can influence RBC EPA + DHA. We collected information on the number of servings of tuna or nonfried fish consumed per month, as well as on age, gender, ethnicity, smoking status, the presence of diabetes, and body mass index (BMI) in 163 adults in Kansas City who were not taking fish oil supplements. The average RBC EPA + DHA in this population was 4.9 ± 2.1%. On a multivariate analysis, four factors significantly and independently influenced the Omega-3 Index: fish servings, age, BMI, and diabetes. The Index increased by 0.24 units with each additional monthly serving of tuna or nonfried fish (P <0.0001), and by 0.5 units for each additional decade in age (P <0.0001). The Index was 1.13% units lower in subjects with diabetes (P = 0.015) and decreased by 0.3% units with each 3-unit increase in BMI (P = 0.001). Gender or smoking status had no effect, and the univariate relationship with ethnicity vanished after controlling for fish intake. Given the importance of n-3 FA in influencing risk for death from CHD, further studies are warranted to delineate the nondietary factors that influence RBC EPA + DHA content.

Original languageEnglish (US)
Pages (from-to)343-347
Number of pages5
JournalLipids
Volume40
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

Fingerprint

Fish
body mass index
Fishes
Body Mass Index
Blood
erythrocytes
Medical problems
Erythrocytes
Tuna
diabetes
tuna
death
nationalities and ethnic groups
fish
Coronary Disease
Smoking
Fish Oils
gender
platelet aggregation
myocardial infarction

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Food Science
  • Biochemistry

Cite this

The impact of age, body mass index, and fish intake on the EPA and DHA content of human erythrocytes. / Sands, Scott A.; Reid, Kimberly J.; Windsor, Sheryl L.; Harris, William.

In: Lipids, Vol. 40, No. 4, 04.2005, p. 343-347.

Research output: Contribution to journalArticle

Sands, Scott A. ; Reid, Kimberly J. ; Windsor, Sheryl L. ; Harris, William. / The impact of age, body mass index, and fish intake on the EPA and DHA content of human erythrocytes. In: Lipids. 2005 ; Vol. 40, No. 4. pp. 343-347.
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