The identification of experimentally induced appendicitis using in vitro nuclear magnetic resonance

Danny Jacobs, John R. Clarke, R. G. Settle, A. K. Sachdeva, James E. Wheeler, Scott O. Trerotola, Gerald L. Wolf, John L. Rombeau

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9 Scopus citations

Abstract

Appendicitis was induced in six New Zealand white rabbits. The appendices from these animals had significantly higher spin-lattice relaxation times, T1, as determined in vitro by nuclear magnetic resonance (NMR) (10 controls vs 6 experimentals, 413 ± 23 vs 455 ± 41, X ± SD, P < (0.02). T1 correlated significantly with the water content of the appendiceal tissue (P < 0.001). These findings suggest that in vivo NMR imaging techniques weighted on T1 might be able to identify human appendicitis noninvasively by detecting localized edema.

Original languageEnglish (US)
Pages (from-to)16-24
Number of pages9
JournalJournal of Surgical Research
Volume39
Issue number1
DOIs
Publication statusPublished - Jan 1 1985
Externally publishedYes

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ASJC Scopus subject areas

  • Surgery

Cite this

Jacobs, D., Clarke, J. R., Settle, R. G., Sachdeva, A. K., Wheeler, J. E., Trerotola, S. O., ... Rombeau, J. L. (1985). The identification of experimentally induced appendicitis using in vitro nuclear magnetic resonance. Journal of Surgical Research, 39(1), 16-24. https://doi.org/10.1016/0022-4804(85)90156-8