The homeobox intestinal differentiation factor CDX2 is selectively expressed in gastrointestinal adenocarcinomas

Vassil Kaimaktchiev, Luigi Terracciano, Luigi Tornillo, Hanspeter Spichtin, Dimitra Stoios, Marcel Bundi, Veselina Korcheva, Martina Mirlacher, Massimo Loda, Guido Sauter, Christopher Corless

Research output: Contribution to journalArticle

147 Citations (Scopus)

Abstract

CDX2 is a homeobox domain-containing transcription factor that is important in the development and differentiation of the intestines. Based on recent studies, CDX2 expression is immunohistochemically detectable in normal colonic enterocytes and is retained in most, but not all, colorectal adenocarcinomas. CDX2 expression has also been documented in a subset of adenocarcinomas arising in the stomach, esophagus and ovary. In this study, we examined CDX2 expression in a series of large tissue microarrays representing 4652 samples of normal and neoplastic tissues. Strong nuclear staining for CDX2 was observed in 97.9% of 140 colonic adenomas, 85.7% of 1109 colonic adenocarcinomas overall and 81.8% of 55 mucinous variants. There was no significant difference in the staining of well-differentiated (96%) and moderately differentiated tumors (90.8%, P = 0.18), but poorly differentiated tumors showed reduced overall expression (56.0%, P

Original languageEnglish (US)
Pages (from-to)1392-1399
Number of pages8
JournalModern Pathology
Volume17
Issue number11
DOIs
StatePublished - Nov 2004

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Homeobox Genes
Adenocarcinoma
Staining and Labeling
Enterocytes
Adenoma
Esophagus
Intestines
Ovary
Neoplasms
Stomach
Transcription Factors

Keywords

  • CDX2
  • Differentiation
  • Immunohistochemistry
  • Intestinal
  • Marker

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

The homeobox intestinal differentiation factor CDX2 is selectively expressed in gastrointestinal adenocarcinomas. / Kaimaktchiev, Vassil; Terracciano, Luigi; Tornillo, Luigi; Spichtin, Hanspeter; Stoios, Dimitra; Bundi, Marcel; Korcheva, Veselina; Mirlacher, Martina; Loda, Massimo; Sauter, Guido; Corless, Christopher.

In: Modern Pathology, Vol. 17, No. 11, 11.2004, p. 1392-1399.

Research output: Contribution to journalArticle

Kaimaktchiev, V, Terracciano, L, Tornillo, L, Spichtin, H, Stoios, D, Bundi, M, Korcheva, V, Mirlacher, M, Loda, M, Sauter, G & Corless, C 2004, 'The homeobox intestinal differentiation factor CDX2 is selectively expressed in gastrointestinal adenocarcinomas', Modern Pathology, vol. 17, no. 11, pp. 1392-1399. https://doi.org/10.1038/modpathol.3800205
Kaimaktchiev, Vassil ; Terracciano, Luigi ; Tornillo, Luigi ; Spichtin, Hanspeter ; Stoios, Dimitra ; Bundi, Marcel ; Korcheva, Veselina ; Mirlacher, Martina ; Loda, Massimo ; Sauter, Guido ; Corless, Christopher. / The homeobox intestinal differentiation factor CDX2 is selectively expressed in gastrointestinal adenocarcinomas. In: Modern Pathology. 2004 ; Vol. 17, No. 11. pp. 1392-1399.
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