The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia

Yi Xu, Takita Felder Sumter, Raka Bhattacharya, Abeba Tesfaye, Ephraim J. Fuchs, Lisa J. Wood, David L. Huso, Linda M.S. Resar

    Research output: Contribution to journalArticle

    98 Scopus citations

    Abstract

    HMG-I/Y is overexpressed in human cancer, although a direct role for this gene in transformation has not been established. We generated transgenic mice with HMG-I targeted to lymphoid cells. All seven informative founder HMG-I mice developed aggressive lymphoma by a mean age of 4.8 months. Tumors express T-cell markers and are transplantable. We also demonstrate that HMG-I mRNA and protein are increased in human acute lymphocytic leukemia samples. Our results show that HMG-I functions as an oncogene and suggest that it contributes to the pathogenesis of leukemia and other cancers with increased HMG-I expression.

    Original languageEnglish (US)
    Pages (from-to)3371-3375
    Number of pages5
    JournalCancer Research
    Volume64
    Issue number10
    DOIs
    StatePublished - May 15 2004

      Fingerprint

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

    Cite this

    Xu, Y., Sumter, T. F., Bhattacharya, R., Tesfaye, A., Fuchs, E. J., Wood, L. J., Huso, D. L., & Resar, L. M. S. (2004). The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia. Cancer Research, 64(10), 3371-3375. https://doi.org/10.1158/0008-5472.CAN-04-0044