The great escape: Viral strategies to counter BST-2/ tetherin

Janet L. Douglas, Jean K. Gustin, Kasinath Viswanathan, Mandana Mansouri, Ashlee V. Moses, Klaus Früh

Research output: Contribution to journalReview article

95 Scopus citations

Abstract

The interferon-induced BST-2 protein has the unique ability to restrict the egress of HIV-1, Kaposi's sarcoma-associated herpesvirus (KSHV), Ebola virus, and other enveloped viruses. The observation that virions remain attached to the surface of BST-2-expressing cells led to the renaming of BST-2 as "tetherin". However, viral proteins such as HIV-1 Vpu, simian immunodeficiency virus Nef, and KSHV K5 counteract BST-2, thereby allowing mature virions to readily escape from infected cells. Since the anti-viral function of BST-2 was discovered, there has been an explosion of research into several aspects of this intriguing interplay between host and virus. This review focuses on recent work addressing the molecular mechanisms involved in BST-2 restriction of viral egress and the species-specific countermeasures employed by various viruses.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalPLoS pathogens
Volume6
Issue number5
DOIs
StatePublished - May 2010

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Molecular Biology
  • Genetics
  • Virology

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