The FDG lumped constant in normal human brain

Michael M. Graham, Mark Muzi, Alexander M. Spence, Finbarr O'Sullivan, Thomas K. Lewellen, Jeanne M. Link, Kenneth A. Krohn

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

The lumped constant (LC) is a correction factor used to infer glucose metabolic rate (MRglc) from FDG metabolic rate (MRFDG). Methods: LC was determined in normal brain in 10 subjects (4 male, 6 female) by measuring regional MRglc and MRFDG independently using l-11C-glucose and 18F-FDG with dynamic positron tomographic imaging, arterial blood sampling, and region-of-interest time-activity curve analysis with appropriate compartmental models. Results: The mean LC (±SD) for normal brain was found to be 0.89 ± 0.08. The value for cerebellum was slightly lower, 0.78 ± 0.11 (P = 0.006; 2-tailed paired t test). Conclusion: The LC values determined in this study are considerably higher than older values in the literature, probably because of methodologic differences, but agree with a recent study by Hasselbalch.

Original languageEnglish (US)
Pages (from-to)1157-1166
Number of pages10
JournalJournal of Nuclear Medicine
Volume43
Issue number9
StatePublished - Sep 1 2002

Keywords

  • C-glucose
  • FDG
  • Glucose metabolism
  • Lumped constant

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Graham, M. M., Muzi, M., Spence, A. M., O'Sullivan, F., Lewellen, T. K., Link, J. M., & Krohn, K. A. (2002). The FDG lumped constant in normal human brain. Journal of Nuclear Medicine, 43(9), 1157-1166.