Abstract
The lumped constant (LC) is a correction factor used to infer glucose metabolic rate (MRglc) from FDG metabolic rate (MRFDG). Methods: LC was determined in normal brain in 10 subjects (4 male, 6 female) by measuring regional MRglc and MRFDG independently using l-11C-glucose and 18F-FDG with dynamic positron tomographic imaging, arterial blood sampling, and region-of-interest time-activity curve analysis with appropriate compartmental models. Results: The mean LC (±SD) for normal brain was found to be 0.89 ± 0.08. The value for cerebellum was slightly lower, 0.78 ± 0.11 (P = 0.006; 2-tailed paired t test). Conclusion: The LC values determined in this study are considerably higher than older values in the literature, probably because of methodologic differences, but agree with a recent study by Hasselbalch.
Original language | English (US) |
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Pages (from-to) | 1157-1166 |
Number of pages | 10 |
Journal | Journal of Nuclear Medicine |
Volume | 43 |
Issue number | 9 |
State | Published - Sep 2002 |
Externally published | Yes |
Keywords
- C-glucose
- FDG
- Glucose metabolism
- Lumped constant
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging