The Fanconi Family Adds a Fraternal Twin

Markus Grompe, Henri van de Vrugt

Research output: Contribution to journalShort survey

27 Scopus citations

Abstract

The Fanconi anemia (FA) pathway plays an important role in DNA repair. In a recent issue of Cell, Smogorzewska et al. (2007) now demonstrate that FANCD2 has a paralog, FANCI. FANCI and FANCD2 form the "ID" complex that loads onto chromatin after DNA damage. Like FANCD2, monoubiquitination of FANCI requires the FA core complex. Importantly, FANCI and FANCD2 monoubiquitination is codependent, suggesting a novel mechanism in ubiquitin conjugation.

Original languageEnglish (US)
Pages (from-to)661-662
Number of pages2
JournalDevelopmental Cell
Volume12
Issue number5
DOIs
StatePublished - May 8 2007

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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