The epsilon subunit confers fast channel gating on multiple classes of acetylcholine receptors

P. Camacho, Y. Liu, G. Mandel, P. Brehm

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

During vertebrate skeletal muscle development, multiple forms of long- open-time (slow-type) ACh receptor channels are replaced by at least two different types of short-open-time (fast-type) ACh receptors. Expression of ACh receptors in Xenopus oocytes indicates that the substitution of an ε subunit for a γ subunit may account for both types of fast-gated channel types in adult muscle. Unlike the various forms of the embryonic receptor, in which functional diversity is achieved through alterations in subunit composition, the two major fast-gated forms expressed in oocytes have identical subunit composition. These findings provide a structural basis for both types of short-open-time ACh receptor types found in adult muscle.

Original languageEnglish (US)
Pages (from-to)605-613
Number of pages9
JournalJournal of Neuroscience
Volume13
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • ACh
  • Xenopus
  • development
  • oocyte
  • patch clamp
  • receptor
  • subunit

ASJC Scopus subject areas

  • Neuroscience(all)

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