The effects of serum testosterone, estradiol, and sex hormone binding globulin levels on fracture risk in older men

Erin S. LeBlanc, Carrie Nielson, Lynn Marshall, Jodi Lapidus, Elizabeth Barrett-Connor, Kristine E. Ensrud, Andrew R. Hoffman, Gail Laughlin, Claes Ohlsson, Eric Orwoll

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

Context: The relationship between sex steroids and fracture is poorly understood. Objective: The objective of the study was to examine associations between nonvertebral fracture risk and bioavailable estradiol (bioE2), bioavailable testosterone (bioT), and SHBG. Design: This was a case-cohort study. Setting: The Osteoporotic Fractures in Men Study (MrOS) was conducted in a prospective U.S. cohort in 5995 community-dwelling men 65 yr old or older. Participants: Participants included a subcohort of 1436 randomly chosen white men plus all 446 minorities and all those with incident hip and other nonvertebral fractures. Main Outcome Measures: Baseline testosterone and estradiol were measured by mass spectrometry (MS) and SHBG by RIA. Results: Men with the lowest bioE2 (59.1 nM) had greater risk of all nonvertebral fractures [adjusted hazard ratio (HR) [95% confidence interval]: 1.5 (1.2-1.9) and 1.4 (1.1-21.8), respectively]. Men with the lowest bioT (

Original languageEnglish (US)
Pages (from-to)3337-3346
Number of pages10
JournalJournal of Clinical Endocrinology and Metabolism
Volume94
Issue number9
DOIs
StatePublished - Sep 2009

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Sex Hormone-Binding Globulin
Testosterone
Estradiol
Serum
Independent Living
Osteoporotic Fractures
Mass spectrometry
Hip
Mass Spectrometry
Hazards
Cohort Studies
Steroids
Outcome Assessment (Health Care)
Confidence Intervals

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

The effects of serum testosterone, estradiol, and sex hormone binding globulin levels on fracture risk in older men. / LeBlanc, Erin S.; Nielson, Carrie; Marshall, Lynn; Lapidus, Jodi; Barrett-Connor, Elizabeth; Ensrud, Kristine E.; Hoffman, Andrew R.; Laughlin, Gail; Ohlsson, Claes; Orwoll, Eric.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 9, 09.2009, p. 3337-3346.

Research output: Contribution to journalArticle

LeBlanc, Erin S. ; Nielson, Carrie ; Marshall, Lynn ; Lapidus, Jodi ; Barrett-Connor, Elizabeth ; Ensrud, Kristine E. ; Hoffman, Andrew R. ; Laughlin, Gail ; Ohlsson, Claes ; Orwoll, Eric. / The effects of serum testosterone, estradiol, and sex hormone binding globulin levels on fracture risk in older men. In: Journal of Clinical Endocrinology and Metabolism. 2009 ; Vol. 94, No. 9. pp. 3337-3346.
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