The effects of prolactin on rat ovarian function

Abraham K. Munabi, Veronica Mericq, Michele C S Koppelman, Marie C. Gelato, Abe M. Macher, Barry D. Albertson, Donald (Lynn) Loriaux, Fernando Cassorla.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Hyperprolactinemia has been associated with several reproductive disorders. To investigate whether hyperprolactinemia directly affects rat ovarian function, we examined the ovarian histopathology and the activities of the four ovarian enzymes 3β-hydroxysteroid dehydrogenase (3β-HSD), 17-hydroxylase (17-OH), 17,20-desmolase (17,20-D) and aromatase in hyperprolactinemic rats and controls. Hypophysectomized, gonadotropin-treated Fisher rats were made hyperprolactinemic by isografting pituitary glands under the kidney capsule. The control animals received skeletal muscle. The ovaries were resected, pooled according to prolactin levels and microsomal enzyme activities were measured from each pool. Prolactin (PRL) levels were 344 ± 23 ng/ml in the hyperprolactinemic rats and 18 ± 5 ng/ml in the controls (p

Original languageEnglish (US)
Pages (from-to)631-637
Number of pages7
JournalSteroids
Volume43
Issue number6
DOIs
StatePublished - 1984
Externally publishedYes

Fingerprint

Prolactin
Rats
Hyperprolactinemia
3-Hydroxysteroid Dehydrogenases
Isogeneic Transplantation
Steroid 17-alpha-Hydroxylase
Aromatase
Enzyme activity
Pituitary Gland
Enzymes
Mixed Function Oxygenases
Gonadotropins
Capsules
Muscle
Ovary
Animals
Skeletal Muscle
Kidney

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Molecular Biology

Cite this

Munabi, A. K., Mericq, V., Koppelman, M. C. S., Gelato, M. C., Macher, A. M., Albertson, B. D., ... Cassorla., F. (1984). The effects of prolactin on rat ovarian function. Steroids, 43(6), 631-637. https://doi.org/10.1016/0039-128X(84)90025-4

The effects of prolactin on rat ovarian function. / Munabi, Abraham K.; Mericq, Veronica; Koppelman, Michele C S; Gelato, Marie C.; Macher, Abe M.; Albertson, Barry D.; Loriaux, Donald (Lynn); Cassorla., Fernando.

In: Steroids, Vol. 43, No. 6, 1984, p. 631-637.

Research output: Contribution to journalArticle

Munabi, AK, Mericq, V, Koppelman, MCS, Gelato, MC, Macher, AM, Albertson, BD, Loriaux, DL & Cassorla., F 1984, 'The effects of prolactin on rat ovarian function', Steroids, vol. 43, no. 6, pp. 631-637. https://doi.org/10.1016/0039-128X(84)90025-4
Munabi AK, Mericq V, Koppelman MCS, Gelato MC, Macher AM, Albertson BD et al. The effects of prolactin on rat ovarian function. Steroids. 1984;43(6):631-637. https://doi.org/10.1016/0039-128X(84)90025-4
Munabi, Abraham K. ; Mericq, Veronica ; Koppelman, Michele C S ; Gelato, Marie C. ; Macher, Abe M. ; Albertson, Barry D. ; Loriaux, Donald (Lynn) ; Cassorla., Fernando. / The effects of prolactin on rat ovarian function. In: Steroids. 1984 ; Vol. 43, No. 6. pp. 631-637.
@article{950215adfa594866b3f24b60392014d9,
title = "The effects of prolactin on rat ovarian function",
abstract = "Hyperprolactinemia has been associated with several reproductive disorders. To investigate whether hyperprolactinemia directly affects rat ovarian function, we examined the ovarian histopathology and the activities of the four ovarian enzymes 3β-hydroxysteroid dehydrogenase (3β-HSD), 17-hydroxylase (17-OH), 17,20-desmolase (17,20-D) and aromatase in hyperprolactinemic rats and controls. Hypophysectomized, gonadotropin-treated Fisher rats were made hyperprolactinemic by isografting pituitary glands under the kidney capsule. The control animals received skeletal muscle. The ovaries were resected, pooled according to prolactin levels and microsomal enzyme activities were measured from each pool. Prolactin (PRL) levels were 344 ± 23 ng/ml in the hyperprolactinemic rats and 18 ± 5 ng/ml in the controls (p",
author = "Munabi, {Abraham K.} and Veronica Mericq and Koppelman, {Michele C S} and Gelato, {Marie C.} and Macher, {Abe M.} and Albertson, {Barry D.} and Loriaux, {Donald (Lynn)} and Fernando Cassorla.",
year = "1984",
doi = "10.1016/0039-128X(84)90025-4",
language = "English (US)",
volume = "43",
pages = "631--637",
journal = "Steroids",
issn = "0039-128X",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - The effects of prolactin on rat ovarian function

AU - Munabi, Abraham K.

AU - Mericq, Veronica

AU - Koppelman, Michele C S

AU - Gelato, Marie C.

AU - Macher, Abe M.

AU - Albertson, Barry D.

AU - Loriaux, Donald (Lynn)

AU - Cassorla., Fernando

PY - 1984

Y1 - 1984

N2 - Hyperprolactinemia has been associated with several reproductive disorders. To investigate whether hyperprolactinemia directly affects rat ovarian function, we examined the ovarian histopathology and the activities of the four ovarian enzymes 3β-hydroxysteroid dehydrogenase (3β-HSD), 17-hydroxylase (17-OH), 17,20-desmolase (17,20-D) and aromatase in hyperprolactinemic rats and controls. Hypophysectomized, gonadotropin-treated Fisher rats were made hyperprolactinemic by isografting pituitary glands under the kidney capsule. The control animals received skeletal muscle. The ovaries were resected, pooled according to prolactin levels and microsomal enzyme activities were measured from each pool. Prolactin (PRL) levels were 344 ± 23 ng/ml in the hyperprolactinemic rats and 18 ± 5 ng/ml in the controls (p

AB - Hyperprolactinemia has been associated with several reproductive disorders. To investigate whether hyperprolactinemia directly affects rat ovarian function, we examined the ovarian histopathology and the activities of the four ovarian enzymes 3β-hydroxysteroid dehydrogenase (3β-HSD), 17-hydroxylase (17-OH), 17,20-desmolase (17,20-D) and aromatase in hyperprolactinemic rats and controls. Hypophysectomized, gonadotropin-treated Fisher rats were made hyperprolactinemic by isografting pituitary glands under the kidney capsule. The control animals received skeletal muscle. The ovaries were resected, pooled according to prolactin levels and microsomal enzyme activities were measured from each pool. Prolactin (PRL) levels were 344 ± 23 ng/ml in the hyperprolactinemic rats and 18 ± 5 ng/ml in the controls (p

UR - http://www.scopus.com/inward/record.url?scp=0021734915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021734915&partnerID=8YFLogxK

U2 - 10.1016/0039-128X(84)90025-4

DO - 10.1016/0039-128X(84)90025-4

M3 - Article

C2 - 6335928

AN - SCOPUS:0021734915

VL - 43

SP - 631

EP - 637

JO - Steroids

JF - Steroids

SN - 0039-128X

IS - 6

ER -