The effects of maternal indomethacin therapy on human fetal branch pulmonary arterial vascular impedance

Juha Rasanen, R. H. Debbs, D. C. Wood, S. Weiner, J. C. Huhta

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective. To examine whether maternal indomethacin therapy affects human fetal pulmonary arterial vascular impedance without constriction of the ductus arteriosus and to determine the changes in the pulmonary arterial vascular impedance in the presence of ductal constriction. Study design. In this cross-sectional study, 52 normal fetuses without ductal constriction (Study group I) and 11 fetuses with ductal constriction (Study group II) during maternal indomethacin therapy between 24 and 34 weeks of gestation were examined by Doppler echo-cardiography. Blood velocity waveforms across the proximal right or left pulmonary artery were obtained and the pulsatility index (PI) of the proximal pulmonary arteries was calculated. Results. In the control group, the proximal pulmonary artery PI was higher (p <0.0001) at 24-25 weeks (n = 7) (3.73 ± 0.33; mean ± SD) than at 33-34 weeks of gestation (n = 11) (2.98 ± 0.27). The PI was constantly greater (p <0.005) in Study group I than in the control group. However, in this group the mean average weekly decrease in the PI of the proximal pulmonary arteries was similar to that in the control group. After 26 weeks of gestation, the PI values in Study group II were significantly higher than in the control group (27 weeks: 4.12 vs 3.34 (p <0.005); 30 weeks: 4.48 vs. 3.14 (p <0.0001); 34 weeks: 4.96 vs. 3.00 (p <0.0001), respectively). Conclusions. Human fetal pulmonary arterial vascular impedance is increased by maternal indomethacin therapy even without ductal constriction. In the presence of ductal constriction, the magnitude of the increase in the vascular impedance is related to the gestational age.

Original languageEnglish (US)
Pages (from-to)112-116
Number of pages5
JournalUltrasound in Obstetrics and Gynecology
Volume13
Issue number2
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Electric Impedance
Constriction
Indomethacin
Blood Vessels
therapy
Mothers
impedance
Lung
Pulmonary Artery
constrictions
arteries
Control Groups
Pregnancy
Fetus
Therapeutics
fetuses
Ductus Arteriosus
Gestational Age
echocardiography
Cross-Sectional Studies

Keywords

  • Doppler
  • Hemodynamics
  • Physiology
  • Prostaglandin inhibitors
  • Pulmonary circulation
  • Ultrasound

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Reproductive Medicine
  • Acoustics and Ultrasonics

Cite this

The effects of maternal indomethacin therapy on human fetal branch pulmonary arterial vascular impedance. / Rasanen, Juha; Debbs, R. H.; Wood, D. C.; Weiner, S.; Huhta, J. C.

In: Ultrasound in Obstetrics and Gynecology, Vol. 13, No. 2, 1999, p. 112-116.

Research output: Contribution to journalArticle

Rasanen, Juha ; Debbs, R. H. ; Wood, D. C. ; Weiner, S. ; Huhta, J. C. / The effects of maternal indomethacin therapy on human fetal branch pulmonary arterial vascular impedance. In: Ultrasound in Obstetrics and Gynecology. 1999 ; Vol. 13, No. 2. pp. 112-116.
@article{5e73fc9601c6465da245ae5d79bc5e66,
title = "The effects of maternal indomethacin therapy on human fetal branch pulmonary arterial vascular impedance",
abstract = "Objective. To examine whether maternal indomethacin therapy affects human fetal pulmonary arterial vascular impedance without constriction of the ductus arteriosus and to determine the changes in the pulmonary arterial vascular impedance in the presence of ductal constriction. Study design. In this cross-sectional study, 52 normal fetuses without ductal constriction (Study group I) and 11 fetuses with ductal constriction (Study group II) during maternal indomethacin therapy between 24 and 34 weeks of gestation were examined by Doppler echo-cardiography. Blood velocity waveforms across the proximal right or left pulmonary artery were obtained and the pulsatility index (PI) of the proximal pulmonary arteries was calculated. Results. In the control group, the proximal pulmonary artery PI was higher (p <0.0001) at 24-25 weeks (n = 7) (3.73 ± 0.33; mean ± SD) than at 33-34 weeks of gestation (n = 11) (2.98 ± 0.27). The PI was constantly greater (p <0.005) in Study group I than in the control group. However, in this group the mean average weekly decrease in the PI of the proximal pulmonary arteries was similar to that in the control group. After 26 weeks of gestation, the PI values in Study group II were significantly higher than in the control group (27 weeks: 4.12 vs 3.34 (p <0.005); 30 weeks: 4.48 vs. 3.14 (p <0.0001); 34 weeks: 4.96 vs. 3.00 (p <0.0001), respectively). Conclusions. Human fetal pulmonary arterial vascular impedance is increased by maternal indomethacin therapy even without ductal constriction. In the presence of ductal constriction, the magnitude of the increase in the vascular impedance is related to the gestational age.",
keywords = "Doppler, Hemodynamics, Physiology, Prostaglandin inhibitors, Pulmonary circulation, Ultrasound",
author = "Juha Rasanen and Debbs, {R. H.} and Wood, {D. C.} and S. Weiner and Huhta, {J. C.}",
year = "1999",
doi = "10.1046/j.1469-0705.1999.13020112.x",
language = "English (US)",
volume = "13",
pages = "112--116",
journal = "Ultrasound in Obstetrics and Gynecology",
issn = "0960-7692",
publisher = "John Wiley and Sons Ltd",
number = "2",

}

TY - JOUR

T1 - The effects of maternal indomethacin therapy on human fetal branch pulmonary arterial vascular impedance

AU - Rasanen, Juha

AU - Debbs, R. H.

AU - Wood, D. C.

AU - Weiner, S.

AU - Huhta, J. C.

PY - 1999

Y1 - 1999

N2 - Objective. To examine whether maternal indomethacin therapy affects human fetal pulmonary arterial vascular impedance without constriction of the ductus arteriosus and to determine the changes in the pulmonary arterial vascular impedance in the presence of ductal constriction. Study design. In this cross-sectional study, 52 normal fetuses without ductal constriction (Study group I) and 11 fetuses with ductal constriction (Study group II) during maternal indomethacin therapy between 24 and 34 weeks of gestation were examined by Doppler echo-cardiography. Blood velocity waveforms across the proximal right or left pulmonary artery were obtained and the pulsatility index (PI) of the proximal pulmonary arteries was calculated. Results. In the control group, the proximal pulmonary artery PI was higher (p <0.0001) at 24-25 weeks (n = 7) (3.73 ± 0.33; mean ± SD) than at 33-34 weeks of gestation (n = 11) (2.98 ± 0.27). The PI was constantly greater (p <0.005) in Study group I than in the control group. However, in this group the mean average weekly decrease in the PI of the proximal pulmonary arteries was similar to that in the control group. After 26 weeks of gestation, the PI values in Study group II were significantly higher than in the control group (27 weeks: 4.12 vs 3.34 (p <0.005); 30 weeks: 4.48 vs. 3.14 (p <0.0001); 34 weeks: 4.96 vs. 3.00 (p <0.0001), respectively). Conclusions. Human fetal pulmonary arterial vascular impedance is increased by maternal indomethacin therapy even without ductal constriction. In the presence of ductal constriction, the magnitude of the increase in the vascular impedance is related to the gestational age.

AB - Objective. To examine whether maternal indomethacin therapy affects human fetal pulmonary arterial vascular impedance without constriction of the ductus arteriosus and to determine the changes in the pulmonary arterial vascular impedance in the presence of ductal constriction. Study design. In this cross-sectional study, 52 normal fetuses without ductal constriction (Study group I) and 11 fetuses with ductal constriction (Study group II) during maternal indomethacin therapy between 24 and 34 weeks of gestation were examined by Doppler echo-cardiography. Blood velocity waveforms across the proximal right or left pulmonary artery were obtained and the pulsatility index (PI) of the proximal pulmonary arteries was calculated. Results. In the control group, the proximal pulmonary artery PI was higher (p <0.0001) at 24-25 weeks (n = 7) (3.73 ± 0.33; mean ± SD) than at 33-34 weeks of gestation (n = 11) (2.98 ± 0.27). The PI was constantly greater (p <0.005) in Study group I than in the control group. However, in this group the mean average weekly decrease in the PI of the proximal pulmonary arteries was similar to that in the control group. After 26 weeks of gestation, the PI values in Study group II were significantly higher than in the control group (27 weeks: 4.12 vs 3.34 (p <0.005); 30 weeks: 4.48 vs. 3.14 (p <0.0001); 34 weeks: 4.96 vs. 3.00 (p <0.0001), respectively). Conclusions. Human fetal pulmonary arterial vascular impedance is increased by maternal indomethacin therapy even without ductal constriction. In the presence of ductal constriction, the magnitude of the increase in the vascular impedance is related to the gestational age.

KW - Doppler

KW - Hemodynamics

KW - Physiology

KW - Prostaglandin inhibitors

KW - Pulmonary circulation

KW - Ultrasound

UR - http://www.scopus.com/inward/record.url?scp=0033005034&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033005034&partnerID=8YFLogxK

U2 - 10.1046/j.1469-0705.1999.13020112.x

DO - 10.1046/j.1469-0705.1999.13020112.x

M3 - Article

C2 - 10079490

AN - SCOPUS:0033005034

VL - 13

SP - 112

EP - 116

JO - Ultrasound in Obstetrics and Gynecology

JF - Ultrasound in Obstetrics and Gynecology

SN - 0960-7692

IS - 2

ER -