The effects of dietary cholesterol on experimental diabetic nephropathy.

M. E. Cooper, D. Vranes, D. A. Vranes, T. J. Allen, S. Panagiotopoulos, R. Komers, G. Jerums

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Hyperlipidaemia has been previously shown to accelerate various models of renal disease. The present study has evaluated the effects of dietary cholesterol supplementation on functional and structural aspects of experimental diabetic nephropathy. Control and streptozotocin diabetic male Sprague Dawley rats were randomized to receive a normal diet or a high cholesterol (4% cholesterol + 1% cholic acid) diet. After 32 weeks, serum lipids, glycaemic control, urinary albumin excretion and glomerular ultrastructural parameters were evaluated in the 4 groups. Diabetes was associated with increased total cholesterol and triglyceride levels. Cholesterol supplementation increased total and decreased HDL-cholesterol in control and diabetic rats. Diabetes increased albuminuria but cholesterol supplementation did not influence urinary albumin excretion. In diabetic rats, glomerular basement membrane thickness and glomerular volume were increased but cholesterol supplementation did not influence any glomerular ultrastructural parameter. In control rats, increased dietary cholesterol intake led to an increase in blood pressure and glomerular volume. In contrast to other models of renal disease, experimental diabetic nephropathy does not appear to be exacerbated by dietary cholesterol supplementation.

Original languageEnglish (US)
Pages (from-to)159-169
Number of pages11
JournalDiabetes Research
Volume22
Issue number4
StatePublished - 1993
Externally publishedYes

Fingerprint

Dietary Cholesterol
Diabetic Nephropathies
Cholesterol
Dietary Supplements
Albumins
Diet
Kidney
Cholic Acid
Glomerular Basement Membrane
Albuminuria
Streptozocin
Hyperlipidemias
HDL Cholesterol
Sprague Dawley Rats
Triglycerides
Blood Pressure
Lipids
Serum

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Cooper, M. E., Vranes, D., Vranes, D. A., Allen, T. J., Panagiotopoulos, S., Komers, R., & Jerums, G. (1993). The effects of dietary cholesterol on experimental diabetic nephropathy. Diabetes Research, 22(4), 159-169.

The effects of dietary cholesterol on experimental diabetic nephropathy. / Cooper, M. E.; Vranes, D.; Vranes, D. A.; Allen, T. J.; Panagiotopoulos, S.; Komers, R.; Jerums, G.

In: Diabetes Research, Vol. 22, No. 4, 1993, p. 159-169.

Research output: Contribution to journalArticle

Cooper, ME, Vranes, D, Vranes, DA, Allen, TJ, Panagiotopoulos, S, Komers, R & Jerums, G 1993, 'The effects of dietary cholesterol on experimental diabetic nephropathy.', Diabetes Research, vol. 22, no. 4, pp. 159-169.
Cooper ME, Vranes D, Vranes DA, Allen TJ, Panagiotopoulos S, Komers R et al. The effects of dietary cholesterol on experimental diabetic nephropathy. Diabetes Research. 1993;22(4):159-169.
Cooper, M. E. ; Vranes, D. ; Vranes, D. A. ; Allen, T. J. ; Panagiotopoulos, S. ; Komers, R. ; Jerums, G. / The effects of dietary cholesterol on experimental diabetic nephropathy. In: Diabetes Research. 1993 ; Vol. 22, No. 4. pp. 159-169.
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