The effects of dietary cholesterol-lowering on psychological symptoms: A randomised controlled study

Gerdi Weidner, Sonja L. Connor, Glenn T. Gerhard, P. Barton Duell, William E. Connor

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The relationship of plasma cholesterol-reducing interventions to emotional states, such as depression and hostility, remains a topic of debate. The present study employed a randomised, controlled design, and was conducted at a clinical research center to test the effect of dietary cholesterol-lowering on psychological symptoms. Ten women and eight men were randomly assigned to one of two counterbalanced diet cycles (low-fat versus high-fat diet; isocaloric; 6 weeks each; separated by a washout period). Analyses for repeated measures revealed that the low-fat diet significantly reduced total, LDL and HDL cholesterol, when compared with baseline and the high-fat diet. As expected, weight remained unchanged. Ratings of depression, hostility and global severity of psychological symptoms as measured by the SCL-90-R also improved significantly on the low-fat, high-complex carbohydrate diet when compared with baseline. These results suggest that plasma cholesterol-lowering in the context of a low-fat, high-complex carbohydrate diet may have a beneficial effect on psychological symptoms.

Original languageEnglish (US)
Pages (from-to)255-261
Number of pages7
JournalPsychology, Health and Medicine
Volume14
Issue number3
DOIs
StatePublished - May 1 2009

Keywords

  • Cholesterol-lowering
  • Depression
  • Diet
  • Hostility

ASJC Scopus subject areas

  • Clinical Psychology
  • Applied Psychology
  • Psychiatry and Mental health

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