The effect of serum from multiple sclerosis patients in remission on the incubated rat brain slices

Gregory Konat, Halina Offner, Ib Zeeberg

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Addition of human serum to incubated rat cerebral slices induced increased generation of myelin-related, membranous fragments floating on 0.32 M sucrose. Sera from 20 healthy subjects and 19 patients with various neurological disorders were equally active in this respect. On the other hand, the myelin-degrading activity of sera from 20 multiple sclerosis patients in remission was found to be significantly elevated by about 50%. The present findings support the contention that the serum of multiple sclerosis patients possesses increased potency to induce myelin sheath alterations.

Original languageEnglish (US)
Pages (from-to)363-366
Number of pages4
JournalJournal of the Neurological Sciences
Volume60
Issue number3
DOIs
StatePublished - 1983
Externally publishedYes

Fingerprint

Multiple Sclerosis
Myelin Sheath
Brain
Serum
Nervous System Diseases
Sucrose
Healthy Volunteers

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

The effect of serum from multiple sclerosis patients in remission on the incubated rat brain slices. / Konat, Gregory; Offner, Halina; Zeeberg, Ib.

In: Journal of the Neurological Sciences, Vol. 60, No. 3, 1983, p. 363-366.

Research output: Contribution to journalArticle

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