TY - JOUR
T1 - The effect of serum from multiple sclerosis patients in remission on the incubated rat brain slices
AU - Konat, Gregory
AU - Offner, Halina
AU - Zeeberg, Ib
N1 - Funding Information:
This study was supported by the Danish Multiple Sclerosis Society.
PY - 1983
Y1 - 1983
N2 - Addition of human serum to incubated rat cerebral slices induced increased generation of myelin-related, membranous fragments floating on 0.32 M sucrose. Sera from 20 healthy subjects and 19 patients with various neurological disorders were equally active in this respect. On the other hand, the myelin-degrading activity of sera from 20 multiple sclerosis patients in remission was found to be significantly elevated by about 50%. The present findings support the contention that the serum of multiple sclerosis patients possesses increased potency to induce myelin sheath alterations.
AB - Addition of human serum to incubated rat cerebral slices induced increased generation of myelin-related, membranous fragments floating on 0.32 M sucrose. Sera from 20 healthy subjects and 19 patients with various neurological disorders were equally active in this respect. On the other hand, the myelin-degrading activity of sera from 20 multiple sclerosis patients in remission was found to be significantly elevated by about 50%. The present findings support the contention that the serum of multiple sclerosis patients possesses increased potency to induce myelin sheath alterations.
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U2 - 10.1016/0022-510X(83)90146-6
DO - 10.1016/0022-510X(83)90146-6
M3 - Article
C2 - 6631442
AN - SCOPUS:0020506512
SN - 0022-510X
VL - 60
SP - 363
EP - 366
JO - Journal of the neurological sciences
JF - Journal of the neurological sciences
IS - 3
ER -