The effect of serum from multiple sclerosis patients in remission on the incubated rat brain slices

Gregory Konat, Halina Offner, Ib Zeeberg

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Addition of human serum to incubated rat cerebral slices induced increased generation of myelin-related, membranous fragments floating on 0.32 M sucrose. Sera from 20 healthy subjects and 19 patients with various neurological disorders were equally active in this respect. On the other hand, the myelin-degrading activity of sera from 20 multiple sclerosis patients in remission was found to be significantly elevated by about 50%. The present findings support the contention that the serum of multiple sclerosis patients possesses increased potency to induce myelin sheath alterations.

Original languageEnglish (US)
Pages (from-to)363-366
Number of pages4
JournalJournal of the neurological sciences
Volume60
Issue number3
DOIs
StatePublished - Jan 1 1983

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ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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