The effect of prolonged aspirin therapy on experimental balloon-catheter arterial wall injury

Richard A. Yeager, Dennis Trune, Susamarie Jacobson, Reid S. Connell, William T. Galey, Robert G. Shoemake, R. Mark Vetto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Indications for aspirin following percutaneous transluminal angioplasty are not well defined. Although aspirin 's early antithrombotic effect is believed to be beneficial, the long-term influence of aspirin on myointimal proliferative response following balloon-catheter angioplasty is still being investigated. This study quantitates arterial wall thickening, including intimal hyperplasia, at 4 months following balloon-catheter aortic injury in New Zealand white rabbits (n = 12), comparing aspirin treatment (30 mg/kg) with controls. Aspirin was administered daily for 1 month prior and 4 months following aortic injury. Myointimal proliferation was noted in both groups. The mean area of the intima and media as well as the maximum thickness of the intima were similar (p <05) in both the aspirin treatment and control groups. Cellular hyperplasia was evaluated by media smooth muscle cell counts using an ocular reticle. There was a trend toward higher cell counts with aspirin treatment, although there was no significant difference between the two groups. Prolonged aspirin therapy did not alter the degree of myointimal hyperplasia at 4 months postinjury in our model.

Original languageEnglish (US)
Pages (from-to)5-10
Number of pages6
JournalJournal of Investigative Surgery
Volume3
Issue number1
DOIs
StatePublished - 1990

Fingerprint

Investigational Therapies
Aspirin
Catheters
Wounds and Injuries
Hyperplasia
Cell Count
Tunica Intima
Balloon Angioplasty
Therapeutics
Angioplasty
Smooth Muscle Myocytes
Rabbits
Control Groups

Keywords

  • Myointimal hyperplasia

ASJC Scopus subject areas

  • Surgery

Cite this

The effect of prolonged aspirin therapy on experimental balloon-catheter arterial wall injury. / Yeager, Richard A.; Trune, Dennis; Jacobson, Susamarie; Connell, Reid S.; Galey, William T.; Shoemake, Robert G.; Vetto, R. Mark.

In: Journal of Investigative Surgery, Vol. 3, No. 1, 1990, p. 5-10.

Research output: Contribution to journalArticle

Yeager, Richard A. ; Trune, Dennis ; Jacobson, Susamarie ; Connell, Reid S. ; Galey, William T. ; Shoemake, Robert G. ; Vetto, R. Mark. / The effect of prolonged aspirin therapy on experimental balloon-catheter arterial wall injury. In: Journal of Investigative Surgery. 1990 ; Vol. 3, No. 1. pp. 5-10.
@article{758e062ebd5e4fbe8890314226b28016,
title = "The effect of prolonged aspirin therapy on experimental balloon-catheter arterial wall injury",
abstract = "Indications for aspirin following percutaneous transluminal angioplasty are not well defined. Although aspirin 's early antithrombotic effect is believed to be beneficial, the long-term influence of aspirin on myointimal proliferative response following balloon-catheter angioplasty is still being investigated. This study quantitates arterial wall thickening, including intimal hyperplasia, at 4 months following balloon-catheter aortic injury in New Zealand white rabbits (n = 12), comparing aspirin treatment (30 mg/kg) with controls. Aspirin was administered daily for 1 month prior and 4 months following aortic injury. Myointimal proliferation was noted in both groups. The mean area of the intima and media as well as the maximum thickness of the intima were similar (p <05) in both the aspirin treatment and control groups. Cellular hyperplasia was evaluated by media smooth muscle cell counts using an ocular reticle. There was a trend toward higher cell counts with aspirin treatment, although there was no significant difference between the two groups. Prolonged aspirin therapy did not alter the degree of myointimal hyperplasia at 4 months postinjury in our model.",
keywords = "Myointimal hyperplasia",
author = "Yeager, {Richard A.} and Dennis Trune and Susamarie Jacobson and Connell, {Reid S.} and Galey, {William T.} and Shoemake, {Robert G.} and Vetto, {R. Mark}",
year = "1990",
doi = "10.3109/08941939009140331",
language = "English (US)",
volume = "3",
pages = "5--10",
journal = "Journal of Investigative Surgery",
issn = "0894-1939",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - The effect of prolonged aspirin therapy on experimental balloon-catheter arterial wall injury

AU - Yeager, Richard A.

AU - Trune, Dennis

AU - Jacobson, Susamarie

AU - Connell, Reid S.

AU - Galey, William T.

AU - Shoemake, Robert G.

AU - Vetto, R. Mark

PY - 1990

Y1 - 1990

N2 - Indications for aspirin following percutaneous transluminal angioplasty are not well defined. Although aspirin 's early antithrombotic effect is believed to be beneficial, the long-term influence of aspirin on myointimal proliferative response following balloon-catheter angioplasty is still being investigated. This study quantitates arterial wall thickening, including intimal hyperplasia, at 4 months following balloon-catheter aortic injury in New Zealand white rabbits (n = 12), comparing aspirin treatment (30 mg/kg) with controls. Aspirin was administered daily for 1 month prior and 4 months following aortic injury. Myointimal proliferation was noted in both groups. The mean area of the intima and media as well as the maximum thickness of the intima were similar (p <05) in both the aspirin treatment and control groups. Cellular hyperplasia was evaluated by media smooth muscle cell counts using an ocular reticle. There was a trend toward higher cell counts with aspirin treatment, although there was no significant difference between the two groups. Prolonged aspirin therapy did not alter the degree of myointimal hyperplasia at 4 months postinjury in our model.

AB - Indications for aspirin following percutaneous transluminal angioplasty are not well defined. Although aspirin 's early antithrombotic effect is believed to be beneficial, the long-term influence of aspirin on myointimal proliferative response following balloon-catheter angioplasty is still being investigated. This study quantitates arterial wall thickening, including intimal hyperplasia, at 4 months following balloon-catheter aortic injury in New Zealand white rabbits (n = 12), comparing aspirin treatment (30 mg/kg) with controls. Aspirin was administered daily for 1 month prior and 4 months following aortic injury. Myointimal proliferation was noted in both groups. The mean area of the intima and media as well as the maximum thickness of the intima were similar (p <05) in both the aspirin treatment and control groups. Cellular hyperplasia was evaluated by media smooth muscle cell counts using an ocular reticle. There was a trend toward higher cell counts with aspirin treatment, although there was no significant difference between the two groups. Prolonged aspirin therapy did not alter the degree of myointimal hyperplasia at 4 months postinjury in our model.

KW - Myointimal hyperplasia

UR - http://www.scopus.com/inward/record.url?scp=0025343825&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025343825&partnerID=8YFLogxK

U2 - 10.3109/08941939009140331

DO - 10.3109/08941939009140331

M3 - Article

C2 - 2282348

AN - SCOPUS:0025343825

VL - 3

SP - 5

EP - 10

JO - Journal of Investigative Surgery

JF - Journal of Investigative Surgery

SN - 0894-1939

IS - 1

ER -