The effect of obesity in adolescence on adult health status

Thomas H. Inge, Wendy C. King, Todd M. Jenkins, Anita P. Courcoulas, Mark Mitsnefes, David R. Flum, Bruce Wolfe, Alfons Pomp, Greg F. Dakin, Saurabh Khandelwal, Meg H. Zeller, Mary Horlick, John R. Pender, Jia Yuh Chen, Stephen R. Daniels

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: To test the hypothesis that adolescent obesity would be associated with greater risks of adverse health in severely obese adults. METHODS: Before weight loss surgery, adult participants in the Longitudinal Assessment of Bariatric Surgery-2 underwent detailed anthropometric and comorbidity assessment. Weight status at age 18 was retrospectively determined. Participants who were ≥80% certain of recalled height and weight at age 18 (1502 of 2308) were included. Log binomial regression was used to evaluate whether weight status at age 18 was independently associated with risk of comorbid conditions at time of surgery controlling for potential confounders. RESULTS: Median age and adult body mass index (BMI) were 47 years and 46, respectively. At age 18, 42% of subjects were healthy weight, 29% overweight, 16% class 1 obese, and 13% class ≥2 obese. Compared with healthy weight at age 18, class ≥2 obesity at age 18 independently increased the risk of lower-extremity venous edema with skin manifestations by 435% (P 0001), severe walking limitation by 321% (P 0001), abnormal kidney function by 302% (P 0001), polycystic ovary syndrome by 74% (P = .03), asthma by 48% (P = .01), diabetes by 42% (P 01), obstructive sleep apnea by 25% (P 01), and hypertension (by varying degrees based on age and gender). Conversely, the associated risk of hyperlipidemia was reduced by 61% (P 01). CONCLUSIONS: Severe obesity at age 18 was independently associated with increased risk of several comorbid conditions in adults undergoing bariatric surgery.

Original languageEnglish (US)
Pages (from-to)1098-1104
Number of pages7
JournalPediatrics
Volume132
Issue number6
DOIs
StatePublished - Dec 2013

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Pediatric Obesity
Health Status
Weights and Measures
Bariatric Surgery
Skin Manifestations
Morbid Obesity
Polycystic Ovary Syndrome
Obstructive Sleep Apnea
Hyperlipidemias
Walking
Comorbidity
Weight Loss
Lower Extremity
Edema
Healthy Volunteers
Body Mass Index
Asthma
Obesity
Adolescence
Hypertension

Keywords

  • Bariatric
  • Obesity
  • Weight history

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Arts and Humanities (miscellaneous)
  • Medicine(all)

Cite this

Inge, T. H., King, W. C., Jenkins, T. M., Courcoulas, A. P., Mitsnefes, M., Flum, D. R., ... Daniels, S. R. (2013). The effect of obesity in adolescence on adult health status. Pediatrics, 132(6), 1098-1104. https://doi.org/10.1542/peds.2013-2185

The effect of obesity in adolescence on adult health status. / Inge, Thomas H.; King, Wendy C.; Jenkins, Todd M.; Courcoulas, Anita P.; Mitsnefes, Mark; Flum, David R.; Wolfe, Bruce; Pomp, Alfons; Dakin, Greg F.; Khandelwal, Saurabh; Zeller, Meg H.; Horlick, Mary; Pender, John R.; Chen, Jia Yuh; Daniels, Stephen R.

In: Pediatrics, Vol. 132, No. 6, 12.2013, p. 1098-1104.

Research output: Contribution to journalArticle

Inge, TH, King, WC, Jenkins, TM, Courcoulas, AP, Mitsnefes, M, Flum, DR, Wolfe, B, Pomp, A, Dakin, GF, Khandelwal, S, Zeller, MH, Horlick, M, Pender, JR, Chen, JY & Daniels, SR 2013, 'The effect of obesity in adolescence on adult health status', Pediatrics, vol. 132, no. 6, pp. 1098-1104. https://doi.org/10.1542/peds.2013-2185
Inge TH, King WC, Jenkins TM, Courcoulas AP, Mitsnefes M, Flum DR et al. The effect of obesity in adolescence on adult health status. Pediatrics. 2013 Dec;132(6):1098-1104. https://doi.org/10.1542/peds.2013-2185
Inge, Thomas H. ; King, Wendy C. ; Jenkins, Todd M. ; Courcoulas, Anita P. ; Mitsnefes, Mark ; Flum, David R. ; Wolfe, Bruce ; Pomp, Alfons ; Dakin, Greg F. ; Khandelwal, Saurabh ; Zeller, Meg H. ; Horlick, Mary ; Pender, John R. ; Chen, Jia Yuh ; Daniels, Stephen R. / The effect of obesity in adolescence on adult health status. In: Pediatrics. 2013 ; Vol. 132, No. 6. pp. 1098-1104.
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abstract = "OBJECTIVE: To test the hypothesis that adolescent obesity would be associated with greater risks of adverse health in severely obese adults. METHODS: Before weight loss surgery, adult participants in the Longitudinal Assessment of Bariatric Surgery-2 underwent detailed anthropometric and comorbidity assessment. Weight status at age 18 was retrospectively determined. Participants who were ≥80{\%} certain of recalled height and weight at age 18 (1502 of 2308) were included. Log binomial regression was used to evaluate whether weight status at age 18 was independently associated with risk of comorbid conditions at time of surgery controlling for potential confounders. RESULTS: Median age and adult body mass index (BMI) were 47 years and 46, respectively. At age 18, 42{\%} of subjects were healthy weight, 29{\%} overweight, 16{\%} class 1 obese, and 13{\%} class ≥2 obese. Compared with healthy weight at age 18, class ≥2 obesity at age 18 independently increased the risk of lower-extremity venous edema with skin manifestations by 435{\%} (P 0001), severe walking limitation by 321{\%} (P 0001), abnormal kidney function by 302{\%} (P 0001), polycystic ovary syndrome by 74{\%} (P = .03), asthma by 48{\%} (P = .01), diabetes by 42{\%} (P 01), obstructive sleep apnea by 25{\%} (P 01), and hypertension (by varying degrees based on age and gender). Conversely, the associated risk of hyperlipidemia was reduced by 61{\%} (P 01). CONCLUSIONS: Severe obesity at age 18 was independently associated with increased risk of several comorbid conditions in adults undergoing bariatric surgery.",
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AU - Khandelwal, Saurabh

AU - Zeller, Meg H.

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N2 - OBJECTIVE: To test the hypothesis that adolescent obesity would be associated with greater risks of adverse health in severely obese adults. METHODS: Before weight loss surgery, adult participants in the Longitudinal Assessment of Bariatric Surgery-2 underwent detailed anthropometric and comorbidity assessment. Weight status at age 18 was retrospectively determined. Participants who were ≥80% certain of recalled height and weight at age 18 (1502 of 2308) were included. Log binomial regression was used to evaluate whether weight status at age 18 was independently associated with risk of comorbid conditions at time of surgery controlling for potential confounders. RESULTS: Median age and adult body mass index (BMI) were 47 years and 46, respectively. At age 18, 42% of subjects were healthy weight, 29% overweight, 16% class 1 obese, and 13% class ≥2 obese. Compared with healthy weight at age 18, class ≥2 obesity at age 18 independently increased the risk of lower-extremity venous edema with skin manifestations by 435% (P 0001), severe walking limitation by 321% (P 0001), abnormal kidney function by 302% (P 0001), polycystic ovary syndrome by 74% (P = .03), asthma by 48% (P = .01), diabetes by 42% (P 01), obstructive sleep apnea by 25% (P 01), and hypertension (by varying degrees based on age and gender). Conversely, the associated risk of hyperlipidemia was reduced by 61% (P 01). CONCLUSIONS: Severe obesity at age 18 was independently associated with increased risk of several comorbid conditions in adults undergoing bariatric surgery.

AB - OBJECTIVE: To test the hypothesis that adolescent obesity would be associated with greater risks of adverse health in severely obese adults. METHODS: Before weight loss surgery, adult participants in the Longitudinal Assessment of Bariatric Surgery-2 underwent detailed anthropometric and comorbidity assessment. Weight status at age 18 was retrospectively determined. Participants who were ≥80% certain of recalled height and weight at age 18 (1502 of 2308) were included. Log binomial regression was used to evaluate whether weight status at age 18 was independently associated with risk of comorbid conditions at time of surgery controlling for potential confounders. RESULTS: Median age and adult body mass index (BMI) were 47 years and 46, respectively. At age 18, 42% of subjects were healthy weight, 29% overweight, 16% class 1 obese, and 13% class ≥2 obese. Compared with healthy weight at age 18, class ≥2 obesity at age 18 independently increased the risk of lower-extremity venous edema with skin manifestations by 435% (P 0001), severe walking limitation by 321% (P 0001), abnormal kidney function by 302% (P 0001), polycystic ovary syndrome by 74% (P = .03), asthma by 48% (P = .01), diabetes by 42% (P 01), obstructive sleep apnea by 25% (P 01), and hypertension (by varying degrees based on age and gender). Conversely, the associated risk of hyperlipidemia was reduced by 61% (P 01). CONCLUSIONS: Severe obesity at age 18 was independently associated with increased risk of several comorbid conditions in adults undergoing bariatric surgery.

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