The effect of noise exposure on the aging ear

Geoffrey Shone; Richard A. Altschuler; Josef M. Miller; Alfred L. Nuttall

doi:10.1016/0378-5955(91)90167-8

The effect of noise exposure on the aging ear

Geoffrey Shone, Richard A. Altschuler, Josef M. Miller, Alfred L. Nuttall

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

The effect of noise exposure on auditory sensitivity and inner ear morphology was compared in aged and young mature mice. Hearing thresholds were obtained by auditory evoked brain stem responses (ABR) before and after noise exposure, and hair cell loss was quantified. The study was done in two parts: first to assess the effect of noise exposure on subjects with presbycusis, and second to assess its effect on aged subjects without measurable presbycusis. In the first experiment C57BL/6 mice, with an age-related hearing loss, were used as a model for presbycusis. C57BL/6 mice exhibiting presbycusis were more susceptible to noise injury than age-matched CBA/Ca mice. In the second experiment CBA/Ca mice were used. These mice retain normal hearing even with advancing age. The aged CBA/Ca mice had the same susceptibility to noise injury as young CBA/Ca mice.

Original language	English (US)
Pages (from-to)	173-178
Number of pages	6
Journal	Hearing Research
Volume	56
Issue number	1-2
DOIs	https://doi.org/10.1016/0378-5955(91)90167-8
State	Published - Nov 1991
Externally published	Yes

Keywords

Aging
Mice
Noise-induced hearing loss
Presbycusis

ASJC Scopus subject areas

Sensory Systems

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10.1016/0378-5955(91)90167-8

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title = "The effect of noise exposure on the aging ear",

abstract = "The effect of noise exposure on auditory sensitivity and inner ear morphology was compared in aged and young mature mice. Hearing thresholds were obtained by auditory evoked brain stem responses (ABR) before and after noise exposure, and hair cell loss was quantified. The study was done in two parts: first to assess the effect of noise exposure on subjects with presbycusis, and second to assess its effect on aged subjects without measurable presbycusis. In the first experiment C57BL/6 mice, with an age-related hearing loss, were used as a model for presbycusis. C57BL/6 mice exhibiting presbycusis were more susceptible to noise injury than age-matched CBA/Ca mice. In the second experiment CBA/Ca mice were used. These mice retain normal hearing even with advancing age. The aged CBA/Ca mice had the same susceptibility to noise injury as young CBA/Ca mice.",

keywords = "Aging, Mice, Noise-induced hearing loss, Presbycusis",

author = "Geoffrey Shone and Altschuler, {Richard A.} and Miller, {Josef M.} and Nuttall, {Alfred L.}",

note = "Funding Information: This grant was supportedi n part by NIH grant No. lROlAG08885 and the TWJ Fellowship Program.W e would also like to thank Denise D. Dyson for her assistancein the preparationo f this manuscript.",

year = "1991",

month = nov,

doi = "10.1016/0378-5955(91)90167-8",

language = "English (US)",

volume = "56",

pages = "173--178",

journal = "Hearing Research",

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AU - Shone, Geoffrey

AU - Altschuler, Richard A.

AU - Miller, Josef M.

AU - Nuttall, Alfred L.

N1 - Funding Information: This grant was supportedi n part by NIH grant No. lROlAG08885 and the TWJ Fellowship Program.W e would also like to thank Denise D. Dyson for her assistancein the preparationo f this manuscript.

PY - 1991/11

Y1 - 1991/11

N2 - The effect of noise exposure on auditory sensitivity and inner ear morphology was compared in aged and young mature mice. Hearing thresholds were obtained by auditory evoked brain stem responses (ABR) before and after noise exposure, and hair cell loss was quantified. The study was done in two parts: first to assess the effect of noise exposure on subjects with presbycusis, and second to assess its effect on aged subjects without measurable presbycusis. In the first experiment C57BL/6 mice, with an age-related hearing loss, were used as a model for presbycusis. C57BL/6 mice exhibiting presbycusis were more susceptible to noise injury than age-matched CBA/Ca mice. In the second experiment CBA/Ca mice were used. These mice retain normal hearing even with advancing age. The aged CBA/Ca mice had the same susceptibility to noise injury as young CBA/Ca mice.

AB - The effect of noise exposure on auditory sensitivity and inner ear morphology was compared in aged and young mature mice. Hearing thresholds were obtained by auditory evoked brain stem responses (ABR) before and after noise exposure, and hair cell loss was quantified. The study was done in two parts: first to assess the effect of noise exposure on subjects with presbycusis, and second to assess its effect on aged subjects without measurable presbycusis. In the first experiment C57BL/6 mice, with an age-related hearing loss, were used as a model for presbycusis. C57BL/6 mice exhibiting presbycusis were more susceptible to noise injury than age-matched CBA/Ca mice. In the second experiment CBA/Ca mice were used. These mice retain normal hearing even with advancing age. The aged CBA/Ca mice had the same susceptibility to noise injury as young CBA/Ca mice.

KW - Aging

KW - Mice

KW - Noise-induced hearing loss

KW - Presbycusis

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JO - Hearing Research

JF - Hearing Research

IS - 1-2

ER -

The effect of noise exposure on the aging ear

Abstract

Keywords

ASJC Scopus subject areas

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