The effect of frequent hemodialysis on nutrition and body composition: Frequent Hemodialysis Network Trial

George A. Kaysen; Tom Greene; Brett Larive; Ravindra L. Mehta; Robert M. Lindsay; Tom A. Depner; Yoshio N. Hall; John T. Daugirdas; Glenn M. Chertow; S. Achinger; S. Anderson; L. Appel; R. Apruzzes; J. Atwal; B. Augustine; J. Ayus; J. Bardsley; W. Bay; S. Beach; G. Beck; B. Bharti; J. Briggs; R. Bullas; J. Burkart; J. Burrowes; E. Cabezon; J. Callegari; M. Carter; J. Champagne; C. Chan; W. Chan; J. Chang; A. Cheung; M. Copland; N. Coplon; A. Coppley; S. Dellagrottaglie; A. Derse; A. Dominguez; S. Doss; P. Eggers; G. Eknoyan; R. Escalada; A. Fensterer; F. Finkelstein; Y. Fofie; B. Franzwa; R. Frome; Z. Fu; A. Garg; J. Gassman; P. Gayda; N. Geller; R. Geronemus; W. Goodman; I. Gorodetskaya; F. Gotch; R. Greenwood; R. Grimm; M. Gutierrez; G. Handelman; L. Henderson; A. Hernandez; H. Higgins; A. Hilkin; T. Hostetter; C. Hoy; M. Humphreys; L. Hunsicker; S. James; M. Kariisa; A. Kaufman; T. Kaufman; S. Ke; R. Keene; P. Kimmel; A. Kliger; P. Kotanko; C. Kramer; M. Kuhlmann; S. Kwan; S. Kwok; E. Lacson; E. Leavell; D. Lemus; A. Levin; N. Levin; M. Li; K. Lilli; R. Lockridge; J. Luan; J. MacKrell; R. Manaster; O. Mandaci; R. Mathew; V. Mauck; A. Mazzorato; C. McCulloch; M. McGrath-Chong; S. McLeroy; I. Meisels; B. Miller; P. Mohr; S. Moossavi; A. Nabali; A. Narva; A. Nissenson; D. Ornt; P. Painter; J. Pepas; C. Peterson; A. Pierratos; M. Pipkin; S. Prichard; S. Rajagopalan; R. Ramos; M. Rashid; A. Rastogi; K. Regozo; J. Riley; M. Rivas; M. Rocco; R. Rodriquez; E. Roecker; D. Roger; J. Rogers; I. Salusky; G. Sanz; J. Sanz; B. Schiller-Moran; J. Schlarb; R. Schuessler; G. Schulman; S. Schweitzer; O. Sergeyeva; S. Shah; S. Sherer; M. Sika; L. Sioson; R. Skelton; M. Smith; C. Snell; D. Somers; J. Sonico; E. Spanner; R. Star; D. Steigerwald; J. Stokes; R. Suri; M. Suter; M. Tamura; M. Tarallo; M. Tichy; G. Ting; T. Tran; D. Ulloa; M. Unruh; J. Vassalotti; W. Wallace; E. Waterman; J. Wei; B. Weiss; J. West; K. Wiggins; J. Winchester

doi:10.1038/ki.2012.75

The effect of frequent hemodialysis on nutrition and body composition: Frequent Hemodialysis Network Trial

George A. Kaysen, Tom Greene, Brett Larive, Ravindra L. Mehta, Robert M. Lindsay, Tom A. Depner, Yoshio N. Hall, John T. Daugirdas, Glenn M. Chertow, S. Achinger, S. Anderson, L. Appel, R. Apruzzes, J. Atwal, B. Augustine, J. Ayus, J. Bardsley, W. Bay, S. Beach, G. BeckB. Bharti, J. Briggs, R. Bullas, J. Burkart, J. Burrowes, E. Cabezon, J. Callegari, M. Carter, J. Champagne, C. Chan, W. Chan, J. Chang, A. Cheung, M. Copland, N. Coplon, A. Coppley, S. Dellagrottaglie, A. Derse, A. Dominguez, S. Doss, P. Eggers, G. Eknoyan, R. Escalada, A. Fensterer, F. Finkelstein, Y. Fofie, B. Franzwa, R. Frome, Z. Fu, A. Garg, J. Gassman, P. Gayda, N. Geller, R. Geronemus, W. Goodman, I. Gorodetskaya, F. Gotch, R. Greenwood, R. Grimm, M. Gutierrez, G. Handelman, L. Henderson, A. Hernandez, H. Higgins, A. Hilkin, T. Hostetter, C. Hoy, M. Humphreys, L. Hunsicker, S. James, M. Kariisa, A. Kaufman, T. Kaufman, S. Ke, R. Keene, P. Kimmel, A. Kliger, P. Kotanko, C. Kramer, M. Kuhlmann, S. Kwan, S. Kwok, E. Lacson, E. Leavell, D. Lemus, A. Levin, N. Levin, M. Li, K. Lilli, R. Lockridge, J. Luan, J. MacKrell, R. Manaster, O. Mandaci, R. Mathew, V. Mauck, A. Mazzorato, C. McCulloch, M. McGrath-Chong, S. McLeroy, I. Meisels, B. Miller, P. Mohr, S. Moossavi, A. Nabali, A. Narva, A. Nissenson, D. Ornt, P. Painter, J. Pepas, C. Peterson, A. Pierratos, M. Pipkin, S. Prichard, S. Rajagopalan, R. Ramos, M. Rashid, A. Rastogi, K. Regozo, J. Riley, M. Rivas, M. Rocco, R. Rodriquez, E. Roecker, D. Roger, J. Rogers, I. Salusky, G. Sanz, J. Sanz, B. Schiller-Moran, J. Schlarb, R. Schuessler, G. Schulman, S. Schweitzer, O. Sergeyeva, S. Shah, S. Sherer, M. Sika, L. Sioson, R. Skelton, M. Smith, C. Snell, D. Somers, J. Sonico, E. Spanner, R. Star, D. Steigerwald, J. Stokes, R. Suri, M. Suter, M. Tamura, M. Tarallo, M. Tichy, G. Ting, T. Tran, D. Ulloa, M. Unruh, J. Vassalotti, W. Wallace, E. Waterman, J. Wei, B. Weiss, J. West, K. Wiggins, J. Winchester

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

We investigated the effects of frequency of hemodialysis on nutritional status by analyzing the data in the Frequent Hemodialysis Network Trial. We compared changes in albumin, body weight, and composition among 245 patients randomized to six or three times per week in-center hemodialysis (Daily Trial) and 87 patients randomized to six times per week nocturnal or three times per week conventional hemodialysis, performed largely at home (Nocturnal Trial). In the Daily Trial, there were no significant differences between groups in changes in serum albumin or the equilibrated protein catabolic rate by 12 months. There was a significant relative decrease in predialysis body weight of 1.5±0.2 kg in the six times per week group at 1 month, but this significantly rebounded by 1.3±0.5 kg over the remaining 11 months. Extracellular water (ECW) decreased in the six times per week compared with the three per week hemodialysis group. There were no significant between-group differences in phase angle, intracellular water, or body cell mass (BCM). In the Nocturnal Trial, there were no significant between-group differences in any study parameter. Any gain in 'dry' body weight corresponded to increased adiposity rather than muscle mass but was not statistically significant. Thus, frequent in-center hemodialysis reduced ECW but did not increase serum albumin or BCM while frequent nocturnal hemodialysis yielded no net effect on parameters of nutritional status or body composition.

Original language	English (US)
Pages (from-to)	90-99
Number of pages	10
Journal	Kidney International
Volume	82
Issue number	1
DOIs	https://doi.org/10.1038/ki.2012.75
State	Published - Jul 1 2012
Externally published	Yes

Keywords

chronic hemodialysis
daily hemodialysis
hypoalbuminemia
nutrition
randomized controlled trials

ASJC Scopus subject areas

Nephrology

Access to Document

10.1038/ki.2012.75

Cite this

Kaysen, G. A., Greene, T., Larive, B., Mehta, R. L., Lindsay, R. M., Depner, T. A., Hall, Y. N., Daugirdas, J. T., Chertow, G. M., Achinger, S., Anderson, S., Appel, L., Apruzzes, R., Atwal, J., Augustine, B., Ayus, J., Bardsley, J., Bay, W., Beach, S., ... Winchester, J. (2012). The effect of frequent hemodialysis on nutrition and body composition: Frequent Hemodialysis Network Trial. Kidney International, 82(1), 90-99. https://doi.org/10.1038/ki.2012.75

Kaysen, GA, Greene, T, Larive, B, Mehta, RL, Lindsay, RM, Depner, TA, Hall, YN, Daugirdas, JT, Chertow, GM, Achinger, S, Anderson, S, Appel, L, Apruzzes, R, Atwal, J, Augustine, B, Ayus, J, Bardsley, J, Bay, W, Beach, S, Beck, G, Bharti, B, Briggs, J, Bullas, R, Burkart, J, Burrowes, J, Cabezon, E, Callegari, J, Carter, M, Champagne, J, Chan, C, Chan, W, Chang, J, Cheung, A, Copland, M, Coplon, N, Coppley, A, Dellagrottaglie, S, Derse, A, Dominguez, A, Doss, S, Eggers, P, Eknoyan, G, Escalada, R, Fensterer, A, Finkelstein, F, Fofie, Y, Franzwa, B, Frome, R, Fu, Z, Garg, A, Gassman, J, Gayda, P, Geller, N, Geronemus, R, Goodman, W, Gorodetskaya, I, Gotch, F, Greenwood, R, Grimm, R, Gutierrez, M, Handelman, G, Henderson, L, Hernandez, A, Higgins, H, Hilkin, A, Hostetter, T, Hoy, C, Humphreys, M, Hunsicker, L, James, S, Kariisa, M, Kaufman, A, Kaufman, T, Ke, S, Keene, R, Kimmel, P, Kliger, A, Kotanko, P, Kramer, C, Kuhlmann, M, Kwan, S, Kwok, S, Lacson, E, Leavell, E, Lemus, D, Levin, A, Levin, N, Li, M, Lilli, K, Lockridge, R, Luan, J, MacKrell, J, Manaster, R, Mandaci, O, Mathew, R, Mauck, V, Mazzorato, A, McCulloch, C, McGrath-Chong, M, McLeroy, S, Meisels, I, Miller, B, Mohr, P, Moossavi, S, Nabali, A, Narva, A, Nissenson, A, Ornt, D, Painter, P, Pepas, J, Peterson, C, Pierratos, A, Pipkin, M, Prichard, S, Rajagopalan, S, Ramos, R, Rashid, M, Rastogi, A, Regozo, K, Riley, J, Rivas, M, Rocco, M, Rodriquez, R, Roecker, E, Roger, D, Rogers, J, Salusky, I, Sanz, G, Sanz, J, Schiller-Moran, B, Schlarb, J, Schuessler, R, Schulman, G, Schweitzer, S, Sergeyeva, O, Shah, S, Sherer, S, Sika, M, Sioson, L, Skelton, R, Smith, M, Snell, C, Somers, D, Sonico, J, Spanner, E, Star, R, Steigerwald, D, Stokes, J, Suri, R, Suter, M, Tamura, M, Tarallo, M, Tichy, M, Ting, G, Tran, T, Ulloa, D, Unruh, M, Vassalotti, J, Wallace, W, Waterman, E, Wei, J, Weiss, B, West, J, Wiggins, K & Winchester, J 2012, 'The effect of frequent hemodialysis on nutrition and body composition: Frequent Hemodialysis Network Trial', Kidney International, vol. 82, no. 1, pp. 90-99. https://doi.org/10.1038/ki.2012.75

@article{de4d35f40df74712981a964899ce808c,

title = "The effect of frequent hemodialysis on nutrition and body composition: Frequent Hemodialysis Network Trial",

abstract = "We investigated the effects of frequency of hemodialysis on nutritional status by analyzing the data in the Frequent Hemodialysis Network Trial. We compared changes in albumin, body weight, and composition among 245 patients randomized to six or three times per week in-center hemodialysis (Daily Trial) and 87 patients randomized to six times per week nocturnal or three times per week conventional hemodialysis, performed largely at home (Nocturnal Trial). In the Daily Trial, there were no significant differences between groups in changes in serum albumin or the equilibrated protein catabolic rate by 12 months. There was a significant relative decrease in predialysis body weight of 1.5±0.2 kg in the six times per week group at 1 month, but this significantly rebounded by 1.3±0.5 kg over the remaining 11 months. Extracellular water (ECW) decreased in the six times per week compared with the three per week hemodialysis group. There were no significant between-group differences in phase angle, intracellular water, or body cell mass (BCM). In the Nocturnal Trial, there were no significant between-group differences in any study parameter. Any gain in 'dry' body weight corresponded to increased adiposity rather than muscle mass but was not statistically significant. Thus, frequent in-center hemodialysis reduced ECW but did not increase serum albumin or BCM while frequent nocturnal hemodialysis yielded no net effect on parameters of nutritional status or body composition.",

keywords = "chronic hemodialysis, daily hemodialysis, hypoalbuminemia, nutrition, randomized controlled trials",

author = "Kaysen, {George A.} and Tom Greene and Brett Larive and Mehta, {Ravindra L.} and Lindsay, {Robert M.} and Depner, {Tom A.} and Hall, {Yoshio N.} and Daugirdas, {John T.} and Chertow, {Glenn M.} and S. Achinger and S. Anderson and L. Appel and R. Apruzzes and J. Atwal and B. Augustine and J. Ayus and J. Bardsley and W. Bay and S. Beach and G. Beck and B. Bharti and J. Briggs and R. Bullas and J. Burkart and J. Burrowes and E. Cabezon and J. Callegari and M. Carter and J. Champagne and C. Chan and W. Chan and J. Chang and A. Cheung and M. Copland and N. Coplon and A. Coppley and S. Dellagrottaglie and A. Derse and A. Dominguez and S. Doss and P. Eggers and G. Eknoyan and R. Escalada and A. Fensterer and F. Finkelstein and Y. Fofie and B. Franzwa and R. Frome and Z. Fu and A. Garg and J. Gassman and P. Gayda and N. Geller and R. Geronemus and W. Goodman and I. Gorodetskaya and F. Gotch and R. Greenwood and R. Grimm and M. Gutierrez and G. Handelman and L. Henderson and A. Hernandez and H. Higgins and A. Hilkin and T. Hostetter and C. Hoy and M. Humphreys and L. Hunsicker and S. James and M. Kariisa and A. Kaufman and T. Kaufman and S. Ke and R. Keene and P. Kimmel and A. Kliger and P. Kotanko and C. Kramer and M. Kuhlmann and S. Kwan and S. Kwok and E. Lacson and E. Leavell and D. Lemus and A. Levin and N. Levin and M. Li and K. Lilli and R. Lockridge and J. Luan and J. MacKrell and R. Manaster and O. Mandaci and R. Mathew and V. Mauck and A. Mazzorato and C. McCulloch and M. McGrath-Chong and S. McLeroy and I. Meisels and B. Miller and P. Mohr and S. Moossavi and A. Nabali and A. Narva and A. Nissenson and D. Ornt and P. Painter and J. Pepas and C. Peterson and A. Pierratos and M. Pipkin and S. Prichard and S. Rajagopalan and R. Ramos and M. Rashid and A. Rastogi and K. Regozo and J. Riley and M. Rivas and M. Rocco and R. Rodriquez and E. Roecker and D. Roger and J. Rogers and I. Salusky and G. Sanz and J. Sanz and B. Schiller-Moran and J. Schlarb and R. Schuessler and G. Schulman and S. Schweitzer and O. Sergeyeva and S. Shah and S. Sherer and M. Sika and L. Sioson and R. Skelton and M. Smith and C. Snell and D. Somers and J. Sonico and E. Spanner and R. Star and D. Steigerwald and J. Stokes and R. Suri and M. Suter and M. Tamura and M. Tarallo and M. Tichy and G. Ting and T. Tran and D. Ulloa and M. Unruh and J. Vassalotti and W. Wallace and E. Waterman and J. Wei and B. Weiss and J. West and K. Wiggins and J. Winchester",

note = "Funding Information: Members of the FHN Trial Group are Achinger S, Anderson S, Appel L, Apruzzes R, Atwal J, Augustine B, Ayus J, Bardsley J, Bay W, Beach S, Beck G, Bharti B, Briggs J, Bullas R, Burkart J, Burrowes J, Cabezon E, Callegari J, Carter M, Champagne J, Chan C, Chan W, Chang J, Chertow G, Cheung A, Copland M, Coplon N, Coppley A, Daugirdas J, Dellagrottaglie S, Depner T, Derse A, Dominguez A, Doss S, Eggers P, Eknoyan G, Escalada R, Fensterer A, Finkelstein F, Fofie Y, Franzwa B, Frome R, Fu Z, Garg A, Gassman J, Gayda P, Geller N, Geronemus R, Goodman W, Gorodetskaya I, Gotch F, Greene T, Greenwood R, Grimm R, Gutierrez M, Hall Y, Handelman G, Henderson L, Hernandez A, Higgins H, Hilkin A, Hostetter T, Hoy C, Humphreys M, Hunsicker L, James S, Kariisa M, Kaufman A, Kaufman T, Kaysen G, Ke S, Keene R, Kimmel P, Kliger A, Kotanko P, Kramer C, Kuhlmann M, Kwan S, Kwok S, Lacson E, Larive B, Leavell E, Lemus D, Levin A, Levin N, Li M, Lilli K, Lindsay R, Lockridge R, Luan J, MacKrell J, Manaster R, Mandaci O, Mathew R, Mauck V, Mazzorato A, McCulloch C, McGrath-Chong M, McLeroy S, Mehta R, Meisels I, Miller B, Mohr P, Moossavi S, Nabali A, Narva A, Nissenson A, Ornt D, Painter P, Pepas J, Peterson C, Pierratos A, Pipkin M, Prichard S, Rajagopalan S, Ramos R, Rashid M, Rastogi A, Regozo K, Riley J, Rivas M, Rocco M, Rodriquez R, Roecker E, Roger D, Rogers J, Salusky I, Sanz G, Sanz J, Schiller-Moran B, Schlarb J, Schuessler R, Schulman G, Schweitzer S, Sergeyeva O, Shah S, Sherer S, Sika M, Sioson L, Skelton R, Smith M, Snell C, Somers D, Sonico J, Spanner E, Star R, Steigerwald D, Stokes J, Suri R, Suter M, Tamura M, Tarallo M, Tichy M, Ting G, Tran T, Ulloa D, Unruh M, Vassalotti J, Wallace W, Waterman E, Wei J, Weiss B, West J, Wiggins K, and Winchester J. The FHN Trials were supported by the National Institutes of Health (NIH), National Institutes of Diabetes and Digestive and Kidney Diseases, the Centers for Medicare and Medicaid Services, and the NIH Research Foundation. Contributors to the NIH Foundation in support of the FHN Trials included Amgen, Baxter, and Dialysis Clinics. Additional support was provided by DaVita, Dialysis Clinics, Fresenius Medical Care, Renal Advantage, Renal Research Institute, and Satellite Healthcare.",

year = "2012",

month = jul,

day = "1",

doi = "10.1038/ki.2012.75",

language = "English (US)",

volume = "82",

pages = "90--99",

journal = "Kidney International",

issn = "0085-2538",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - The effect of frequent hemodialysis on nutrition and body composition

T2 - Frequent Hemodialysis Network Trial

AU - Kaysen, George A.

AU - Greene, Tom

AU - Larive, Brett

AU - Mehta, Ravindra L.

AU - Lindsay, Robert M.

AU - Depner, Tom A.

AU - Hall, Yoshio N.

AU - Daugirdas, John T.

AU - Chertow, Glenn M.

AU - Achinger, S.

AU - Anderson, S.

AU - Appel, L.

AU - Apruzzes, R.

AU - Atwal, J.

AU - Augustine, B.

AU - Ayus, J.

AU - Bardsley, J.

AU - Bay, W.

AU - Beach, S.

AU - Beck, G.

AU - Bharti, B.

AU - Briggs, J.

AU - Bullas, R.

AU - Burkart, J.

AU - Burrowes, J.

AU - Cabezon, E.

AU - Callegari, J.

AU - Carter, M.

AU - Champagne, J.

AU - Chan, C.

AU - Chan, W.

AU - Chang, J.

AU - Cheung, A.

AU - Copland, M.

AU - Coplon, N.

AU - Coppley, A.

AU - Dellagrottaglie, S.

AU - Derse, A.

AU - Dominguez, A.

AU - Doss, S.

AU - Eggers, P.

AU - Eknoyan, G.

AU - Escalada, R.

AU - Fensterer, A.

AU - Finkelstein, F.

AU - Fofie, Y.

AU - Franzwa, B.

AU - Frome, R.

AU - Fu, Z.

AU - Garg, A.

AU - Gassman, J.

AU - Gayda, P.

AU - Geller, N.

AU - Geronemus, R.

AU - Goodman, W.

AU - Gorodetskaya, I.

AU - Gotch, F.

AU - Greenwood, R.

AU - Grimm, R.

AU - Gutierrez, M.

AU - Handelman, G.

AU - Henderson, L.

AU - Hernandez, A.

AU - Higgins, H.

AU - Hilkin, A.

AU - Hostetter, T.

AU - Hoy, C.

AU - Humphreys, M.

AU - Hunsicker, L.

AU - James, S.

AU - Kariisa, M.

AU - Kaufman, A.

AU - Kaufman, T.

AU - Ke, S.

AU - Keene, R.

AU - Kimmel, P.

AU - Kliger, A.

AU - Kotanko, P.

AU - Kramer, C.

AU - Kuhlmann, M.

AU - Kwan, S.

AU - Kwok, S.

AU - Lacson, E.

AU - Leavell, E.

AU - Lemus, D.

AU - Levin, A.

AU - Levin, N.

AU - Li, M.

AU - Lilli, K.

AU - Lockridge, R.

AU - Luan, J.

AU - MacKrell, J.

AU - Manaster, R.

AU - Mandaci, O.

AU - Mathew, R.

AU - Mauck, V.

AU - Mazzorato, A.

AU - McCulloch, C.

AU - McGrath-Chong, M.

AU - McLeroy, S.

AU - Meisels, I.

AU - Miller, B.

AU - Mohr, P.

AU - Moossavi, S.

AU - Nabali, A.

AU - Narva, A.

AU - Nissenson, A.

AU - Ornt, D.

AU - Painter, P.

AU - Pepas, J.

AU - Peterson, C.

AU - Pierratos, A.

AU - Pipkin, M.

AU - Prichard, S.

AU - Rajagopalan, S.

AU - Ramos, R.

AU - Rashid, M.

AU - Rastogi, A.

AU - Regozo, K.

AU - Riley, J.

AU - Rivas, M.

AU - Rocco, M.

AU - Rodriquez, R.

AU - Roecker, E.

AU - Roger, D.

AU - Rogers, J.

AU - Salusky, I.

AU - Sanz, G.

AU - Sanz, J.

AU - Schiller-Moran, B.

AU - Schlarb, J.

AU - Schuessler, R.

AU - Schulman, G.

AU - Schweitzer, S.

AU - Sergeyeva, O.

AU - Shah, S.

AU - Sherer, S.

AU - Sika, M.

AU - Sioson, L.

AU - Skelton, R.

AU - Smith, M.

AU - Snell, C.

AU - Somers, D.

AU - Sonico, J.

AU - Spanner, E.

AU - Star, R.

AU - Steigerwald, D.

AU - Stokes, J.

AU - Suri, R.

AU - Suter, M.

AU - Tamura, M.

AU - Tarallo, M.

AU - Tichy, M.

AU - Ting, G.

AU - Tran, T.

AU - Ulloa, D.

AU - Unruh, M.

AU - Vassalotti, J.

AU - Wallace, W.

AU - Waterman, E.

AU - Wei, J.

AU - Weiss, B.

AU - West, J.

AU - Wiggins, K.

AU - Winchester, J.

N1 - Funding Information: Members of the FHN Trial Group are Achinger S, Anderson S, Appel L, Apruzzes R, Atwal J, Augustine B, Ayus J, Bardsley J, Bay W, Beach S, Beck G, Bharti B, Briggs J, Bullas R, Burkart J, Burrowes J, Cabezon E, Callegari J, Carter M, Champagne J, Chan C, Chan W, Chang J, Chertow G, Cheung A, Copland M, Coplon N, Coppley A, Daugirdas J, Dellagrottaglie S, Depner T, Derse A, Dominguez A, Doss S, Eggers P, Eknoyan G, Escalada R, Fensterer A, Finkelstein F, Fofie Y, Franzwa B, Frome R, Fu Z, Garg A, Gassman J, Gayda P, Geller N, Geronemus R, Goodman W, Gorodetskaya I, Gotch F, Greene T, Greenwood R, Grimm R, Gutierrez M, Hall Y, Handelman G, Henderson L, Hernandez A, Higgins H, Hilkin A, Hostetter T, Hoy C, Humphreys M, Hunsicker L, James S, Kariisa M, Kaufman A, Kaufman T, Kaysen G, Ke S, Keene R, Kimmel P, Kliger A, Kotanko P, Kramer C, Kuhlmann M, Kwan S, Kwok S, Lacson E, Larive B, Leavell E, Lemus D, Levin A, Levin N, Li M, Lilli K, Lindsay R, Lockridge R, Luan J, MacKrell J, Manaster R, Mandaci O, Mathew R, Mauck V, Mazzorato A, McCulloch C, McGrath-Chong M, McLeroy S, Mehta R, Meisels I, Miller B, Mohr P, Moossavi S, Nabali A, Narva A, Nissenson A, Ornt D, Painter P, Pepas J, Peterson C, Pierratos A, Pipkin M, Prichard S, Rajagopalan S, Ramos R, Rashid M, Rastogi A, Regozo K, Riley J, Rivas M, Rocco M, Rodriquez R, Roecker E, Roger D, Rogers J, Salusky I, Sanz G, Sanz J, Schiller-Moran B, Schlarb J, Schuessler R, Schulman G, Schweitzer S, Sergeyeva O, Shah S, Sherer S, Sika M, Sioson L, Skelton R, Smith M, Snell C, Somers D, Sonico J, Spanner E, Star R, Steigerwald D, Stokes J, Suri R, Suter M, Tamura M, Tarallo M, Tichy M, Ting G, Tran T, Ulloa D, Unruh M, Vassalotti J, Wallace W, Waterman E, Wei J, Weiss B, West J, Wiggins K, and Winchester J. The FHN Trials were supported by the National Institutes of Health (NIH), National Institutes of Diabetes and Digestive and Kidney Diseases, the Centers for Medicare and Medicaid Services, and the NIH Research Foundation. Contributors to the NIH Foundation in support of the FHN Trials included Amgen, Baxter, and Dialysis Clinics. Additional support was provided by DaVita, Dialysis Clinics, Fresenius Medical Care, Renal Advantage, Renal Research Institute, and Satellite Healthcare.

PY - 2012/7/1

Y1 - 2012/7/1

N2 - We investigated the effects of frequency of hemodialysis on nutritional status by analyzing the data in the Frequent Hemodialysis Network Trial. We compared changes in albumin, body weight, and composition among 245 patients randomized to six or three times per week in-center hemodialysis (Daily Trial) and 87 patients randomized to six times per week nocturnal or three times per week conventional hemodialysis, performed largely at home (Nocturnal Trial). In the Daily Trial, there were no significant differences between groups in changes in serum albumin or the equilibrated protein catabolic rate by 12 months. There was a significant relative decrease in predialysis body weight of 1.5±0.2 kg in the six times per week group at 1 month, but this significantly rebounded by 1.3±0.5 kg over the remaining 11 months. Extracellular water (ECW) decreased in the six times per week compared with the three per week hemodialysis group. There were no significant between-group differences in phase angle, intracellular water, or body cell mass (BCM). In the Nocturnal Trial, there were no significant between-group differences in any study parameter. Any gain in 'dry' body weight corresponded to increased adiposity rather than muscle mass but was not statistically significant. Thus, frequent in-center hemodialysis reduced ECW but did not increase serum albumin or BCM while frequent nocturnal hemodialysis yielded no net effect on parameters of nutritional status or body composition.

AB - We investigated the effects of frequency of hemodialysis on nutritional status by analyzing the data in the Frequent Hemodialysis Network Trial. We compared changes in albumin, body weight, and composition among 245 patients randomized to six or three times per week in-center hemodialysis (Daily Trial) and 87 patients randomized to six times per week nocturnal or three times per week conventional hemodialysis, performed largely at home (Nocturnal Trial). In the Daily Trial, there were no significant differences between groups in changes in serum albumin or the equilibrated protein catabolic rate by 12 months. There was a significant relative decrease in predialysis body weight of 1.5±0.2 kg in the six times per week group at 1 month, but this significantly rebounded by 1.3±0.5 kg over the remaining 11 months. Extracellular water (ECW) decreased in the six times per week compared with the three per week hemodialysis group. There were no significant between-group differences in phase angle, intracellular water, or body cell mass (BCM). In the Nocturnal Trial, there were no significant between-group differences in any study parameter. Any gain in 'dry' body weight corresponded to increased adiposity rather than muscle mass but was not statistically significant. Thus, frequent in-center hemodialysis reduced ECW but did not increase serum albumin or BCM while frequent nocturnal hemodialysis yielded no net effect on parameters of nutritional status or body composition.

KW - chronic hemodialysis

KW - daily hemodialysis

KW - hypoalbuminemia

KW - nutrition

KW - randomized controlled trials

UR - http://www.scopus.com/inward/record.url?scp=84862494377&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862494377&partnerID=8YFLogxK

U2 - 10.1038/ki.2012.75

DO - 10.1038/ki.2012.75

M3 - Article

C2 - 22456602

AN - SCOPUS:84862494377

SN - 0085-2538

VL - 82

SP - 90

EP - 99

JO - Kidney International

JF - Kidney International

IS - 1

ER -

The effect of frequent hemodialysis on nutrition and body composition: Frequent Hemodialysis Network Trial

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