TY - JOUR
T1 - The effect of dietary protein on the efficacy of L-dopa
T2 - A double-blind study
AU - Tsui, J. K.
AU - Ross, S.
AU - Poulin, K.
AU - Douglas, J.
AU - Postnikoff, D.
AU - Calne, S.
AU - Woodward, W.
AU - Calne, D. B.
PY - 1989/4
Y1 - 1989/4
N2 - We randomly placed 10 parkinsonian patients on high- and low-protein dieta that tasted and looked alike, each for 1 week. All patients were taking l-dopa and carbidopa with or without other antiparkinson medications; medications remained unchanged. A “blind” physician recorded the modified Columbia scores, objective measurements of rigidity, movement velocity, and pegboard tests three times a day for 5 days during each week. The patients recorded fluctuations hour to hour. We measured serial blood L-dopa levels on day 4 of each week. Performance was significantly better while the patients were on low-protein diets. These results did not correlate with blood L-dopa levels, which had higher peaks in three patients while they were on high-protein diets despite inferior performance and increased number of “off” hours. Thus, high dietary protein probably affects the efficacy of L-dopa at a central level.
AB - We randomly placed 10 parkinsonian patients on high- and low-protein dieta that tasted and looked alike, each for 1 week. All patients were taking l-dopa and carbidopa with or without other antiparkinson medications; medications remained unchanged. A “blind” physician recorded the modified Columbia scores, objective measurements of rigidity, movement velocity, and pegboard tests three times a day for 5 days during each week. The patients recorded fluctuations hour to hour. We measured serial blood L-dopa levels on day 4 of each week. Performance was significantly better while the patients were on low-protein diets. These results did not correlate with blood L-dopa levels, which had higher peaks in three patients while they were on high-protein diets despite inferior performance and increased number of “off” hours. Thus, high dietary protein probably affects the efficacy of L-dopa at a central level.
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U2 - 10.1212/wnl.39.4.549
DO - 10.1212/wnl.39.4.549
M3 - Article
C2 - 2494567
AN - SCOPUS:0024582276
SN - 0028-3878
VL - 39
SP - 549
EP - 552
JO - Neurology
JF - Neurology
IS - 4
ER -