The effect of dietary protein on the efficacy of L-dopa: A double-blind study

J. K. Tsui, S. Ross, K. Poulin, J. Douglas, D. Postnikoff, S. Calne, William Woodward, D. B. Calne

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

We randomly placed 10 parkinsonian patients on high- and low-protein dieta that tasted and looked alike, each for 1 week. All patients were taking l-dopa and carbidopa with or without other antiparkinson medications; medications remained unchanged. A “blind” physician recorded the modified Columbia scores, objective measurements of rigidity, movement velocity, and pegboard tests three times a day for 5 days during each week. The patients recorded fluctuations hour to hour. We measured serial blood L-dopa levels on day 4 of each week. Performance was significantly better while the patients were on low-protein diets. These results did not correlate with blood L-dopa levels, which had higher peaks in three patients while they were on high-protein diets despite inferior performance and increased number of “off” hours. Thus, high dietary protein probably affects the efficacy of L-dopa at a central level.

Original languageEnglish (US)
Pages (from-to)549-552
Number of pages4
JournalNeurology
Volume39
Issue number4
StatePublished - 1989

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Dietary Proteins
Levodopa
Double-Blind Method
Carbidopa
Protein-Restricted Diet
Dihydroxyphenylalanine
Proteins
Protein
Efficacy
Diet
Physicians

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Tsui, J. K., Ross, S., Poulin, K., Douglas, J., Postnikoff, D., Calne, S., ... Calne, D. B. (1989). The effect of dietary protein on the efficacy of L-dopa: A double-blind study. Neurology, 39(4), 549-552.

The effect of dietary protein on the efficacy of L-dopa : A double-blind study. / Tsui, J. K.; Ross, S.; Poulin, K.; Douglas, J.; Postnikoff, D.; Calne, S.; Woodward, William; Calne, D. B.

In: Neurology, Vol. 39, No. 4, 1989, p. 549-552.

Research output: Contribution to journalArticle

Tsui, JK, Ross, S, Poulin, K, Douglas, J, Postnikoff, D, Calne, S, Woodward, W & Calne, DB 1989, 'The effect of dietary protein on the efficacy of L-dopa: A double-blind study', Neurology, vol. 39, no. 4, pp. 549-552.
Tsui JK, Ross S, Poulin K, Douglas J, Postnikoff D, Calne S et al. The effect of dietary protein on the efficacy of L-dopa: A double-blind study. Neurology. 1989;39(4):549-552.
Tsui, J. K. ; Ross, S. ; Poulin, K. ; Douglas, J. ; Postnikoff, D. ; Calne, S. ; Woodward, William ; Calne, D. B. / The effect of dietary protein on the efficacy of L-dopa : A double-blind study. In: Neurology. 1989 ; Vol. 39, No. 4. pp. 549-552.
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