The effect of age on human cone and rod ganzfeld electroretinograms

R. G. Weleber

Research output: Contribution to journalArticlepeer-review

192 Scopus citations


The ganzfeld-evoked electroretinogram (ERG) is the most effective measure of the mass electrical response of cones and rods; however, all variables affecting the various components of the ERG have not been identified. The scotopic b-wave amplitude has been appreciated to be age-dependent, but little or no information exists in the literature regarding age dependency for other components. Linear regression analysis against age and multiple regression analysis against age and log intensity of the stimulus were performed on ERG responses from 24 prospectively normal subjects. Significant age dependency was found for scotopic rod-mediated b-wave amplitude, scotopic mixed rod-and cone-mediated bx-wave amplitude, and for photopic cone-mediated b-wave amplitude. No significant age correlation was found for dark-adapted cone a-wave amplitude, scotopic cone-mediated x-wave amplitude, scotopic a-wave amplitude from mixed rod and cone responses to bright stimuli, or for implicit times for any scotopic or photopic responses. These findings indicate that for clinical patient evaluation, age-corrected normal ranges derived from linear or multiple regression coefficients should be used for rod- and cone-mediated b-wave response, whereas normal ranges derived from mean and standard deviation are more appropriate for scotopic a-wave amplitude, scotopic cone-mediated x-wave amplitude, and for all implicit times.

Original languageEnglish (US)
Pages (from-to)392-399
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Issue number3
StatePublished - Jan 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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