The development of therapeutic and preventive vaccines for gastric cancer and Helicobacter pylori

Stephen (Steve) Chui, Timothy M. Clay, H. Kim Lyerly, Michael A. Morse

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Gastric cancer is one of the most important worldwide public health problems. Convincing epidemiologic and etiologic associations have been made between the development of gastric cancer and infection with Helicobacter pylori. H. pylori not only has adapted to survive within the harsh environment of the stomach but also is able to modulate and avoid endogenous immune responses. The design and creation of efficacious vaccine strategies against H. pylori requires an understanding of the complex interactions that make up mucosal immunity. An effective vaccine strategy against H. pylori has the potential to affect significantly on population health worldwide.

Original languageEnglish (US)
Pages (from-to)1883-1889
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume14
Issue number8
DOIs
StatePublished - Aug 2005
Externally publishedYes

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Helicobacter pylori
Stomach Neoplasms
Vaccines
Mucosal Immunity
Therapeutics
Stomach
Public Health
Infection
Population
Global Health

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

The development of therapeutic and preventive vaccines for gastric cancer and Helicobacter pylori. / Chui, Stephen (Steve); Clay, Timothy M.; Lyerly, H. Kim; Morse, Michael A.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 14, No. 8, 08.2005, p. 1883-1889.

Research output: Contribution to journalArticle

Chui, Stephen (Steve) ; Clay, Timothy M. ; Lyerly, H. Kim ; Morse, Michael A. / The development of therapeutic and preventive vaccines for gastric cancer and Helicobacter pylori. In: Cancer Epidemiology Biomarkers and Prevention. 2005 ; Vol. 14, No. 8. pp. 1883-1889.
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