The development of therapeutic and preventive vaccines for gastric cancer and Helicobacter pylori

Stephen Y. Chui, Timothy M. Clay, H. Kim Lyerly, Michael A. Morse

    Research output: Contribution to journalReview article

    10 Scopus citations

    Abstract

    Gastric cancer is one of the most important worldwide public health problems. Convincing epidemiologic and etiologic associations have been made between the development of gastric cancer and infection with Helicobacter pylori. H. pylori not only has adapted to survive within the harsh environment of the stomach but also is able to modulate and avoid endogenous immune responses. The design and creation of efficacious vaccine strategies against H. pylori requires an understanding of the complex interactions that make up mucosal immunity. An effective vaccine strategy against H. pylori has the potential to affect significantly on population health worldwide.

    Original languageEnglish (US)
    Pages (from-to)1883-1889
    Number of pages7
    JournalCancer Epidemiology Biomarkers and Prevention
    Volume14
    Issue number8
    DOIs
    StatePublished - Aug 2005

    ASJC Scopus subject areas

    • Epidemiology
    • Oncology

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