The cytoplasmic tail peptide sequence of membrane type-1 matrix metalloproteinase (MT1-MMP) directly binds to gC1qR, a compartment-specific chaperone-like regulatory protein

Dmitri Rozanov, Berhane Ghebrehiwet, Boris I. Ratnikov, Edward Z. Monosov, Elena I. Deryugina, Alex Y. Strongin

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Membrane type-1 matrix metalloproteinase (MT1-MMP), a key enzyme in cell locomotion, is known to be primarily recruited to the leading edge of migrating cells. This raises a possibility that the C-terminal cytoplasmic tail of MT1-MMP interacts with intracellular regulatory proteins, which modulate translocations of the protease across the cell. Here, we demonstrated that MT1-MMP via its cytoplasmic tail directly associates with a chaperone-like compartment-specific regulator gC1qR. Although a direct functional link between these two proteins remains uncertain, our observations suggest that the transient associations of gC1qR with the cytoplasmic tail of MT1-MMP are likely to be involved in the mechanisms regulating presentation of the protease at the tumor cell surface.

Original languageEnglish (US)
Pages (from-to)51-57
Number of pages7
JournalFEBS Letters
Volume527
Issue number1-3
DOIs
StatePublished - Sep 11 2002
Externally publishedYes

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Matrix Metalloproteinase 14
Peptides
Proteins
Peptide Hydrolases
Cell Movement
Tumors
Cells
Enzymes
Neoplasms

Keywords

  • Extracellular matrix
  • gC1qR
  • Internalization
  • Membrane protein
  • Membrane type-1 matrix metalloproteinase
  • Trafficking

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

The cytoplasmic tail peptide sequence of membrane type-1 matrix metalloproteinase (MT1-MMP) directly binds to gC1qR, a compartment-specific chaperone-like regulatory protein. / Rozanov, Dmitri; Ghebrehiwet, Berhane; Ratnikov, Boris I.; Monosov, Edward Z.; Deryugina, Elena I.; Strongin, Alex Y.

In: FEBS Letters, Vol. 527, No. 1-3, 11.09.2002, p. 51-57.

Research output: Contribution to journalArticle

Rozanov, Dmitri ; Ghebrehiwet, Berhane ; Ratnikov, Boris I. ; Monosov, Edward Z. ; Deryugina, Elena I. ; Strongin, Alex Y. / The cytoplasmic tail peptide sequence of membrane type-1 matrix metalloproteinase (MT1-MMP) directly binds to gC1qR, a compartment-specific chaperone-like regulatory protein. In: FEBS Letters. 2002 ; Vol. 527, No. 1-3. pp. 51-57.
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