The continuum of GERD complications

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Complications of chronic gastroesophageal reflux disease (GERD) run the gamut from erosive esophagitis to esophageal cancer, but all are linked to repeated exposure of the esophagus to caustic gastric and duodenal acid. Progression from one complication to another is not clearly established across the GERD continuum, although there is a clear progression from the serious complication of Barren's esophagus to esophageal adenocarcinoma. This review examines the range of complications that can arise from chronic GERD, underscoring the need to view heartburn as a symptom of a potentially serious condition.

Original languageEnglish (US)
Pages (from-to)S33-S50
JournalCleveland Clinic journal of medicine
Issue numberSUPPL. 5
StatePublished - Nov 1 2003

ASJC Scopus subject areas

  • Medicine(all)


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