The contemporary management of cancers of the sinonasal tract in adults

Rajat Thawani, Myung Sun Kim, Asad Arastu, Zizhen Feng, Malinda T. West, Nicholas F. Taflin, Kyaw Zin Thein, Ryan Li, Mathew Geltzeiler, Nancy Lee, Clifton David Fuller, Jennifer R. Grandis, Charalampos S. Floudas, Michael C. Heinrich, Ehab Hanna, Ravi A. Chandra

Research output: Contribution to journalReview articlepeer-review

Abstract

Sinonasal malignancies make up <5% of all head and neck neoplasms, with an incidence of 0.5–1.0 per 100,000. The outcome of these rare malignancies has been poor, whereas significant progress has been made in the management of other cancers. The objective of the current review was to describe the incidence, causes, presentation, diagnosis, treatment, and recent developments of malignancies of the sinonasal tract. The diagnoses covered in this review included sinonasal undifferentiated carcinoma, sinonasal adenocarcinoma, sinonasal squamous cell carcinoma, and esthesioneuroblastoma, which are exclusive to the sinonasal tract. In addition, the authors covered malignances that are likely to be encountered in the sinonasal tract—primary mucosal melanoma, NUT (nuclear protein of the testis) carcinoma, and extranodal natural killer cell/T-cell lymphoma. For the purpose of keeping this review as concise and focused as possible, sarcomas and malignancies that can be classified as salivary gland neoplasms were excluded.

Original languageEnglish (US)
JournalCA Cancer Journal for Clinicians
DOIs
StateAccepted/In press - 2022

Keywords

  • head and neck neoplasms
  • paranasal sinus neoplasms
  • rare diseases
  • sinonasal carcinoma

ASJC Scopus subject areas

  • Hematology
  • Oncology

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