The contact pathway and sepsis

Vikram Raghunathan, Jevgenia Zilberman-Rudenko, Sven R. Olson, Florea Lupu, Owen J.T. McCarty, Joseph J. Shatzel

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

The contact pathway factors XI (FXI) and XII (FXII) have been demonstrated to be largely dispensable for hemostasis, as their absence results in a mild to absent bleeding diathesis. A growing body of literature, however, suggests that the contact pathway contributes to the pathologic host response to certain infectious organisms that produces the often-fatal syndrome known as sepsis. The contact pathway factors serve as a central node connecting inflammation to coagulation, and may offer a potentially safe therapeutic target to mitigate the morbidity and mortality associated with sepsis. Herein, we summarize published in vivo and in vitro data that have explored the roles of the contact pathway in sepsis, and discuss potential clinical applications of novel FXI- and FXII-inhibiting drugs currently under investigation.

Original languageEnglish (US)
Pages (from-to)331-339
Number of pages9
JournalResearch and Practice in Thrombosis and Haemostasis
Volume3
Issue number3
DOIs
StatePublished - Jul 2019

Keywords

  • contact activation
  • factor XI
  • factor XII
  • kallikrein-kinin system
  • sepsis

ASJC Scopus subject areas

  • Hematology

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