The combined effects of N-3 fatty acids and aspirin on hemostatic parameters in man

William Harris, Scott Silveira, Carlos A. Dujovne

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Both fish oils and aspirin are readily available to the consumer as over-the-counter preparations. Since both of these products have been shown to prolong bleeding times, it is possible that hemostasis might be adversely affected in subjects taking them in combination. This study was undertaken to examine the effects of n-3 fatty acids and aspirin on platelet function. Eight healthy men took a total of 485 mg of aspirin over 3 days before beginning two weeks of fish oil supplementation (4.5 g of n-3 fatty acids/day). Subjects continued with fish oil while resuming aspirin treatment for 3 days. Aspirin alone prolonged bleeding times by 34% (p <0.05). Fish oil alone raised bleeding times only slightly (9%; N.S.), but aspirin plus fish oil raised them by 78% (p

Original languageEnglish (US)
Pages (from-to)517-526
Number of pages10
JournalThrombosis Research
Volume57
Issue number4
DOIs
StatePublished - Feb 15 1990
Externally publishedYes

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Omega-3 Fatty Acids
Hemostatics
Fish Oils
Aspirin
Bleeding Time
Hemostasis
Blood Platelets

Keywords

  • aspirin
  • fatty acids
  • Fish oil
  • platelet aggregation
  • unsaturated fats

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

Cite this

The combined effects of N-3 fatty acids and aspirin on hemostatic parameters in man. / Harris, William; Silveira, Scott; Dujovne, Carlos A.

In: Thrombosis Research, Vol. 57, No. 4, 15.02.1990, p. 517-526.

Research output: Contribution to journalArticle

Harris, William ; Silveira, Scott ; Dujovne, Carlos A. / The combined effects of N-3 fatty acids and aspirin on hemostatic parameters in man. In: Thrombosis Research. 1990 ; Vol. 57, No. 4. pp. 517-526.
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