The CD28-B7 costimulatory pathway and its role in autoimmune disease

David Daikh, David Wofsy, John B. Imboden

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

The activation of naive CD4+ T cells requires two discrete signals: a signal delivered by the T cell receptor following recognition of antigen and an accessory signal transduced when costimulatory receptors interact with their ligands. Particularly important in the development of an immune response to foreign antigens is the T cell molecule CD28, which delivers a potent costimulus when engaged by ligands, B7-1 and B7-2, on antigen- presenting cells. It is interesting that blockade of B7 molecules, which disrupts interactions with CD28 and prevents delivery of the CD28 costimulus, also alters the immune responses to self antigens and prevents the development of clinical disease in murine models of systemic and organ- specific autoimunity. Herein we review the roles of CD28 and its B7 ligands in the pathogenesis of auto-immunity, discuss efforts to treat animal models of autoimmunity by modifying the CD28 signal, and consider the mechanisms by which manipulation of the CD28 signal alters the course of experimental auto-immune disease.

Original languageEnglish (US)
Pages (from-to)156-162
Number of pages7
JournalJournal of Leukocyte Biology
Volume62
Issue number2
DOIs
StatePublished - Aug 1997
Externally publishedYes

Keywords

  • Antigen-presenting cells
  • Self antigens

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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