TY - JOUR
T1 - The catalytic mechanism of Escherichia coli aspartate carbamoyltransferase
T2 - A molecular modelling study
AU - Eric Gouaux, J.
AU - Krause, Kurt L.
AU - Lipscomb, William N.
PY - 1987/2/13
Y1 - 1987/2/13
N2 - Based on a molecular modelling study, we propose that the reaction between L-aspartate and carbamoylphosphate, catalyzed by E. coli aspartate carbamoyltransferase, may proceed via a tetrahedral intermediate and that the breakdown of the intermediate is faciliated by an intramolecular proton transfer between the amino group of L-aspartate and a terminal phosphate oxygen of carbamoylphosphate.
AB - Based on a molecular modelling study, we propose that the reaction between L-aspartate and carbamoylphosphate, catalyzed by E. coli aspartate carbamoyltransferase, may proceed via a tetrahedral intermediate and that the breakdown of the intermediate is faciliated by an intramolecular proton transfer between the amino group of L-aspartate and a terminal phosphate oxygen of carbamoylphosphate.
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U2 - 10.1016/0006-291X(87)91497-5
DO - 10.1016/0006-291X(87)91497-5
M3 - Article
C2 - 3548720
AN - SCOPUS:0023152298
SN - 0006-291X
VL - 142
SP - 893
EP - 897
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -